Objectives The aim of our study was to investigate the role of TrkB pathway in tumor occurrence and development for in order to provide theoretical basis to laryngeal cancer therapy. Materials and methods Biological characteristics of the cells were studied by migration tests and colony forming assay. Gene and protein expression analysis was performed by RT-PCR or western blot. in vivo experi...

BACKGROUND Only a prototype laryngeal tube has been compared with the classic LMA for brief periods of anaesthesia. We compared the new laryngeal tube (which had several improvements in design) with the classic LMA. METHODS We randomly allocated 72 patients to receive either the laryngeal tube or an LMA, and compared adequacy of controlled ventilation during anaesthesia (good: clear airway wi...

Foreign body lodgement in the larynx is a rare situation. Our review of the literature revealed no living foreign body in larynx except for laryngeal leeches and anisakiasis. In this article, we report a patient with unusual laryngeal foreign body lodgement: a bee which presented with sudden odynophagia and stinging sensation in throat. The bee was detected on the laryngeal mucosa in indirect l...

Laryngeal sarcoidosis is a rare condition, particularly in the pediatric population. Acute airway intervention may be required severe cases, but guidelines to support therapeutic strategy are absent. Moreover, evidence regarding systemic therapy scarce. This encouraged us report result of management and methotrexate at one-year follow-up child with laryngeal sarcoidosis. A 14-year-old Caucasian...

BACKGROUND AND PURPOSE With a 64-channel multidetector row CT, imaging acquisition during speech, swallowing, or phonation has become feasible. However, the actual benefit of these additional focused images should be critically evaluated with respect to radiation dose. The purpose of this study was to determine if dedicated laryngeal CT using breath-holding and straw-blowing improved the accura...

We investigated the mechanisms of airway protection and bolus transport during retching and vomiting by recording responses of the pharyngeal, laryngeal, and hyoid muscles and comparing them with responses during swallowing and responses of the gastrointestinal tract. Five dogs were chronically instrumented with electrodes on the striated muscles and strain gauges on smooth muscles. Retching an...

The pathogenetic mechanisms of laryngeal airway hyperreactivity (LAH) in patients with extraesophageal reflux are unclear. We recently reported that a laryngeal acid-pepsin insult produces LAH that is mediated through sensitization of the capsaicin-sensitive laryngeal afferent fibers by reactive oxygen species (ROS) in rats. Since ROS may promote the release of ATP from cells, we hypothesized t...

=Abstract=ln situ hybridization using digoxigenin labeled HPV(human papillornaviruses) probes was tried in order to detect the presence of HPV DNA in 27 cases of single and multiple laryngeal papilloma. There were HPV6/11 DNA signals in 17 out of 22 cases of multiple laryngeal papilloma and in all five cases of single laryngeal papilloma. The specific signals were seen focally in the nuclei of ...

following use of a laryngeal mask airway. Anaesthesia 1994; 49: 786–787. 3. Stewart A, Lindsay WA. Bilateral hypoglossal nerve injury following the use of the laryngeal mask airway. Anaesthesia 2002; 57: 264–265. 4. Sommer M, Schuldt M, Runge U, Gielen-Wijffels S, Marcus MA. Bilateral hypoglossal nerve injury following the use of the laryngeal mask without the use of nitrous oxide. Acta Anaesth...

Ten junior doctors with no postgraduate anaesthetic experience attempted to ventilate the lungs of 50 anaesthetized patients, using either a laryngeal mask or a Guedel airway and face mask. Success was defined as the production of two successive tidal volumes exceeding 800 ml within 40 s. The failure rate was significantly greater using the laryngeal mask compared with the face mask (P < 0.05) ...