Amphotropic murine leukemia virus (A-MuLV) utilizes the Pit-2 sodium-dependent phosphate transporter as a cell surface receptor to infect mammalian cells. Previous studies established that infection of cells with A-MuLV resulted in the specific down-modulation of phosphate uptake mediated by Pit-2 and in resistance to superinfection with A-MuLV. To study the mechanisms underlying these phenomen...

➥ lation are familiar and the ‘swing’ of the pressure trace during inspiration and expiration is easily seen on a standard monitor display. These changes are largely the consequence of alterations in intrathoracic pressure (PIT). It is important to recognise that PIT greatly influences the transmural pressure (PTM), which is the actual effective distending pressure of the cardiac chamber, and r...

Let Q = {qj, qz,..., qn / be a set of n points on the plane. The largest empty circle (LEC) problem consists in finding the largest circle C with center in the convex hull of Q such that no point q(C Q lies in the interior of C. Shamos recently outlined an O(n log n) algorithm for solving this problemJ 9) In this paper it is shown that this algorithm does not always work correctly. A different ...

Given a set of blue points and a set of red points in ddimensional space, we show how to find an axis-aligned hyperrectangle that contains no red points and as many blue points as possible. Our algorithm enumerates the set of relevant hyperrectangles (inclusion maximal axisaligned hyperrectangles that do not contain a red point) and counts the number of blue points in each one. The runtime of o...

The incidence of external and internal bitter pit in ‘Cox’s Orange Pippin’ apple (Malus domestics Borkh.) fruit sprayed with normal therapeutic sprays either with or without Ca salts at 2-week intervals during the growing season was determined after 6 weeks of storage over 7 consecutive years. Following harvest, fruit was either vacuum-infiltrated with CaCI2 or received no further treatment. Al...

OBJECTIVE To assess the usability and validity of the Primary Care Practice Improvement Tool (PC-PIT), a practice performance improvement tool based on 13 key elements identified by a systematic review. It was co-created with a range of partners and designed specifically for primary health care. DESIGN This pilot study examined the PC-PIT using a formative assessment framework and mixed-metho...

Gastrin/CCK-B receptors (CCKB-Rs) are present on parietal and enterochromaffin-like cells in the gastric mucosa but not on pit cells in the proliferative zone. Because serum gastrin levels are well correlated with the growth of the gastric pit, we examined whether pit precursor cells express CCKB-Rs using hypergastrinemic transgenic mice and a mouse pit precursor cell line, GSM06. In situ hybri...

It is reasonable to assume that the discrimination of simple visual stimuli depends on the activity of early visual cortical neurons, because simple visual features are supposedly coded in these areas whereas more complex features are coded in late visual areas. Recently, we showed that training monkeys in a coarse orientation discrimination task modified the response properties of single neuro...

Forty-four inbred and four randombred rat strains and 20 inbred mouse strains were examined for their Ah phenotype by determining the induction of liver microsomal aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity (EC 1.14.14.1) by intraperitoneal treatment with either beta-naphthoflavone or 3-methylcholanthrene. All 48 rat strains were found to be Ah-responsive. The maximally induced hydr...

The effect of shading on xylem hydraulic traits and xylem anatomy was studied in hybrid poplar (Populus trichocarpa x deltoides, clone H11-11). Hydraulic measurements conducted on stem segments of 3-month-old saplings grown in shaded (SH) or control light (C) conditions indicated that shading resulted in more vulnerable and less efficient xylem. Air is thought to enter vessels through pores in ...