CD3 zeta and CD3 eta form disulfide-linked homo- or heterodimers important in targeting partially assembled Ti alpha-beta/CD3 gamma delta epsilon T cell receptor (TCR) complexes to the cell surface and transducing stimulatory signals after antigen recognition. Here we identify a new TCR isoform expressed on splenic CD2+, CD3/Ti alpha-beta+, CD4-, CD8-, CD16+, NK1.1+ mouse large granular lymphoc...

BACKGROUND To evaluate the efficacy of extracorporeal photopheresis (ECP) in noncutaneous T-cell lymphoma and large granular lymphocytes leukemia (LGL). PATIENTS AND METHODS We have treated 12 refractory/relapsed patients. Six peripheral T-cell lymphoma (PTCL), one T-lymphoblastic lymphoma and five LGL with blood involvement received six biweekly leukapheresis as induction phase, followed by ...

CD3~" and CD37/form disulfide-linked homoor heterodimers important in targeting partially assembled Tiot-B/CD3qd~e T cell receptor (TCR) complexes to the cell surface and transducing stimulatory signals after antigen recognition. Here we identify a new TCR isoform expressed on splenic CD2 +, CD3/Tic~-/~ +, CD4-, CDS-, CD16 +, NKI.1 + mouse large granular lymphocytes (LGL), which are devoid of C...

A 43-year-old male with a phenotypically homogeneous, expanded subset of T cells presented in 1981 with anemia and neutropenia. The surface antigen phenotype of 99% of the peripheral blood lymphocytes was T3+, T8+, T4-, and they were morphologically large granular lymphocytes (LGL). The same cells comprised 37% of the marrow nucleated cells. Eight months after he presented, the peripheral blood...

Augmentation of natural killer (NK) activity by influenza A/PC and HSV-1 viruses appears to be caused by the induction of interferon (IFN) within the NK cell population itself. These viruses induced high levels of IFN production by human large granular lymphocytes (LGL) that could be readily isolated from peripheral blood by Percoll density gradients. These LGL, which have been previously shown...

Large granular lymphocytes (LGL)' represent a population of lymphoid cells morphologically and functionally distinct from conventional T and B lymphocytes (1), but their exact progenitors as well as differentiation pathway remain largely unclear . We have recently observed that continuous LGL lines could be efficiently generated in vitro by IL-2 from the spleen cells of mice infected with Molon...

Large granular lymphocyte leukemia-associated pure red cell aplasia accounts for a significant portion of secondary pure red cell aplasia cases. However, because of its rarity, long-term responses and relapse rates after immunosuppressive therapy are largely unknown. We conducted a nationwide survey in Japan and collected 185 evaluable patients. Fourteen patients with large granular lymphocyte ...

Large granular lymphocyte and prolymphocytic leukaemias are rare chronic lymphoproliferative disorders. Large granular lymphocyte leukaemias consist of indolent disorders such as T-cell large granular lymphocyte and chronic lymphoproliferative disorder of natural killer cells and the very rare but aggressive natural killer cell leukaemia. Treatment of the indolent large granular lymphocyte leuk...

The considerable center-of-mass energy and luminosity provided by the Large Hadron Collider (LHC) will ensure a discovery reach for new particles which extends well into the multi-TeV region. ATLAS and CMS have carried out many studies of the implications of this capability for Beyond the Standard Model physics. In this paper, we summarize some key results of studies involving non-susy models, ...

The Large Hadron Collider (LHC) at CERN in Geneva (Switzerland) will go into operation in the coming months and will soon enable us to analyse the highest energy collisions ever produced at an accelerator. With a design integrated luminosity of up to 100/fb per year and a centre-of-mass energy of 14 TeV it will not only allow us to probe the Standard Model beyond the TeV scale but also search f...