The mechanical failure of self-piercing rivet (SPR) joints connecting seven series aluminum and high strength steel sheets is investigated, both numerically experimentally. joint mechanisms are characterized for a total four distinct loading modes, including the lap-shear, cross-tension, inclined cross tension coach peel. For analysis underlying influential parameters in each case, designs with...

This paper is concerned with modelling damage and fracture in woven fabric CFRP single-lap bolted joints that fail by net-tension. The approach is based on the assumption that damage (matrix cracking, delamination and fibre tow fracture) initiates and propagates from the hole in a self-similar fashion. A traction-separation law (based on physically meaningful material parameters) is implemented...

BACKGROUND It has been reported that human FOXP3(+) CD4 Tregs express GARP-anchored surface latency-associated peptide (LAP) after activation, based on the use of an anti-human LAP mAb. Murine CD4 Foxp3(+) Tregs have also been reported to express surface LAP, but these studies have been hampered by the lack of suitable anti-mouse LAP mAbs. METHODOLOGY/PRINCIPAL FINDINGS We generated anti-mous...

Beta-lapachone (β-Lap; 3,4-dihydro-2, 2-dimethyl-2H-naphthol[1, 2-b]pyran-5,6-dione) is a novel anti-cancer drug under phase I/II clinical trials. β-Lap has been demonstrated to cause apoptotic and necrotic death in a variety of human cancer cells in vitro and in vivo. The mechanisms underlying the β-Lap toxicity against cancer cells has been controversial. The most recent view is that β-Lap, w...

Cisplatin, a typical anticancer drug, is often used to treat different cancers, and leucine aminopeptidase (LAP) is known to be widely distributed in organisms from bacteria to humans, including various cancer cells. However, cancer cells display different intrinsic or acquired resistance toward cisplatin, and it is unclear whether intracellular LAP plays a role in the intrinsic drug resistance...

High-strength aluminum alloys are of increasing interest to the aerospace and automotive industry for critical high-strength components. B-pillars and door beams being of particular interest to the automotive industry Refill friction stir spot welding (RFSSW) offers an attractive means of joining these difficult-to-weld alloys since bulk melting is avoided and no exit hole is left. In this stud...

Carbon fibre/epoxy composite joints were assembled with Poly-etherether-ketone (PEEK) and Poly-ethylenimine (PEI) films using a co-curing process to prepare single-lap joint specimens. The tested under quasi-static loading conditions at 22 °C 130 fatigue condition. experimental results demonstrated better or comparable structure integrity of the co-cured by PEEK PEI than reference bonded aerosp...

One of the main objectives of thermal modification is to increase the biological durability of wood. In this study the fungal resistance of Norway spruce and Scots pine, thermally modified at 1958C and 2108C, was studied with a lap-joint field test. Untreated pine and spruce and pine impregnated with tributyl tin oxide (TBTO) and copper, chromium and arsenic (CCA) were selected as reference mat...