The adhesion receptors Mac-1, LFA-1, and p150,95 are cell surface alpha/beta heterodimers that play a key role in leukocyte adhesion processes. The genes for Mac-1, LFA-1, and p150,95 alpha subunits have been located to chromosome 16 by means of Southern blot analysis using a series of somatic cell hybrids. Chromosomal in situ hybridization has demonstrated that the genes for the three alpha su...

The identification of catchment functional behavior with regards to water and energy balance is an important step during the parameterization of land surface models. An approach based on time series of thermal infrared (TIR) data from remote sensing is developed and investigated to identify land surface functioning as is represented in the temporal dynamics of land surface temperature (LST). Fo...

Abstract. Functional classification of the road is important to construction sustainable transport systems and proper design facilities. Mobile laser scanning (MLS) point clouds provide accurate dense 3D measurements scenes, while their massive data volume lack structure also bring difficulties in processing. cloud understanding through deep neural networks achieves breakthroughs since PointNet...

Activation of lymphocyte function–associated antigen-1 (LFA-1) by chemokines is fine-tuned by inside-out signaling mechanisms responsible for integrin-mediated adhesion modulation. In the present study, we investigated the possibility of qualitative variability of signaling mechanisms controlling LFA-1 activation in chronic lymphocytic leukemia (CLL) cells. We pursued a multiplexed comparative ...

The adhesion molecules LFA-1 and ICAM-1 are considered to be critically involved in cell fusion and multinucleated giant cell (MGC) formation (1). Alveolar macrophages of patients with pulmonary sarcoidosis show increased expression of LFA-1 and ICAM1 (2) and, importantly, it has been shown that MGC formation can be blocked by anti-LFA-1 and anti-ICAM-1 antibodies (1). LFA-1/ICAM-1 interaction ...

The paper aims to analyze the parameters of prototypes new overvoltage protection devices for power grids—a multi-chamber insulator arrester (MCA) and a long flashover (LFA). article presents research results on determining actual MCA LFA impact characteristics. Moreover, were compared assess effectiveness devices. presented in this will supplement missing information about They make it possibl...

Multigrid methods are popular for solving linear systems derived from discretizing PDEs. Local Fourier analysis (LFA) is a technique investigating and tuning multigrid methods. P-multigrid high-order or spectral finite element methods, especially on unstructured meshes. In this paper, we introduce LFAToolkit.jl, new Julia package LFA of LFAToolkit.jl analyzes preconditioning techniques arbitrar...

Abstract We investigate the impact of five types subsidies granted under European Union Common Agricultural Policy on persistent and transient inefficiency Polish dairy farms. Our research shows that coupled environmental reduce technical inefficiency, while opposite is true for Less Favoured Areas (LFA) other rural subsidies. Simultaneously, environmental, LFA, increase inefficiency. These res...

Many surface receptors and signaling molecules are thought to associate with unique membrane microdomains termed lipid rafts. We examined the involvement of lipid rafts in the activation of leukocyte function-associated antigen-1 (LFA-1). Depletion or sequestration of cholesterol with methyl-beta-cyclodextrin (MCD) or filipin, respectively, strongly inhibited LFA-1-mediated adhesion of T-cell l...

Lymphocytes activate adhesion to intracellular adhesion mlecule 1 (ICAM-1) via leukocyte function associated antigen 1 (LFA-1), their major beta 2 integrin, in response to PMA (phorbol 12-myristate 13-acetate) without an increase in the number of receptors expressed. The molecular details of the mechanism are unknown. To determine the effect of PMA activation on LFA-1 movement within the plasma...