Tympanosclerosis is an abnormal connective tissue reaction with hyaline degeneration and calcification in the tympanic membrane and submucosa of the middle ear. It is an irreversible, non-spesific end-result chronic inflammation or infection of the middle ear. The process occurs in the lamina propria layer of submucosa. A homogenous mass takes place by thickening and fusion of the collagenous f...

Gastric and duodenal pseudomelanosis is a rare endoscopic mucosal finding, characterized by the accumulation of iron in macrophages of the lamina propria of the stomach and duodenum. The clinical significance and long term sequelae have not been clarified yet. However, this benign condition is associated with a variety of clinical conditions, such as essential hypertension, chronic renal failur...

Pseudomelanosis duodeni is characterized by the presence of brownish or blackish pigmentation in the duodenal mucosa identified during endoscopy. Although the pathogenesis is uncertain, it was generally believed that it is sequelae of luminal absorption of iron and sulfide chemicals, which is subsequently deposited in the lamina propria. It is often associated with hemodialysis and oral intake ...

The absorption of adriamycin (ADM) through the rat bladder epithelium was investigated histologically with a fluorescence microscope. ADM permeated through the epithelium into the lamina propria or the inner layer of the muscle within 15 min after instillation, but no further infiltration into the deeper part of the bladder wall was observed thereafter. In addition, fluorescence histological ev...

Intestinal immunity differs from systemic immunity in several aspects and is frequently studied separately. In this work we have analysed the frequency of mononuclear cells spontaneously secreting the cytokines IL-2, IL-4, IL-5, IL-6, IL-10, interferon gamma (IFN-gamma) and tumour necrosis factor (TNF-alpha), in Peyer's patches and lamina propria of small intestine in mice by enzyme linked immu...

Amyloidosis is characterized by an extracellular deposition of insoluble fibrils. Amyloid deposition caused various clinical symptoms associated with affected organs. Secondary amyloidosis without renal involvement and chronic inflammatory conditions is rarely reported. We experienced a case of secondary intestinal amyloidosis presented with recurrent hematochezia and abdominal pain in a 54-yea...

Caecal biopsy specimens from Jamaican children with the Trichuris dysentery syndrome (TDS) and age matched Jamaican controls were investigated by immunohistochemistry and by light microscopy. Biopsy specimens from all children (with TDS and controls) showed a mild to moderate increase in inflammatory cells. Except in the vicinity of the worm, where the epithelium was flattened, there was no oth...