OBJECTIVE To investigate the prevalence of lactose and fructose intolerance in children with chronic abdominal pain. METHODS Hydrogen breath tests were done to detect lactose and fructose malabsorption in 86 children with chronic abdominal pain (44 irritable bowel syndrome, 24 functional abdominal pain and 17 functional abdominal pain syndrome as per Rome III criteria) presenting to a Pediatr...

Oligosaccharides from regular milk and lactose-free were analyzed by Electrospray Ionization interface coupled with Ion Trap Mass Spectrometry (IT-MS). The negative mode mass spectrometry of sugar compositions was obtained either direct infusion Liquid Chromatography (LC). Hexose (Hex) the other oligomeric components observed in both milk. While lactose derivatives (deprotonated dimer, chloride...

pray-dried (SD) lactose was introduced to the pharmaceutical market in the 1960s as an excipient that enables direct compression of formulations in a simple manufacturing process (1). To this day, lactose remains one of the most popular excipients for active pharmaceutical ingredients (APIs) whose dose makes them suitable for direct compression. Several manufacturers make and sell SD lactose, a...

The only carbohydrate in milk is lactose, a disaccharide, which is formed of a molecule of glucose and a molecule of galactose. Cow's milk contains about 5 % lactose and human milk about 6'5-7 %. Lactose is hydrolysed to its monosaccharides principally by a specific enzyme, lactase, which is a f-galactosidase. There are also two other enzymes with ,3-galactosidase activitv, lysosomal acid 3-gal...

Lactose intolerance has been reviewed in published statements by the Protein Advisory Group of the United Nations System,’ the Food and Nutrition Board of the National Research Council,2 and the American Academy of Pediatrics, Committee on Nutrition.’ Each of these statements deals principally with the advisability of encouraging population groups with a high rate of lactose intolerance to cons...

Galactokinase and beta-galactosidase-deficient strains of Streptococcus salivarius were constructed to define the pathways for lactose and galactose catabolism. It was found that S. salivarius does not possess a lactose-specific phosphoenolpyruvate phosphotransferase system (PTS), that intracellular lactose was hydrolyzed by beta-galactosidase, and that galactose is catabolized exclusively thro...

BACKGROUND Lactase enzyme supplements and probiotics with high beta-galactosidase activity may be valid treatment options for the lactose intolerance. Aim of this study was to assess whether supplementation with tilactase or Lactobacillus reuteri when compared to placebo affects hydrogen breath excretion and gastrointestinal symptoms in lactose intolerant patients during lactose breath test (H,...

The purpose of this study was to determine the in vitro deposition of both drug (albuterol sulfate) and carrier (lactose) particles in relation to each other from a dry powder inhaler formulation using an Andersen cascade impactor (ACI) and time of flight aerosol beam spectrometry (TOFABS). In addition, scanning electron microscopy (SEM) combined with X-ray microanalysis was employed to disting...