Small (18-25 microm diam) dorsal root ganglion (DRG) neurons are known to express high levels of tetrodotoxin-resistant (TTX-R) sodium current and the mRNA for the alpha-SNS sodium channel, which encodes a TTX-R channel when expressed in oocytes. These neurons also preferentially express the high affinity receptor for nerve growth factor (NGF), TrkA. Levels of TTX-R sodium current and of alpha-...

It has been recently indicated that relaxation of the guinea-pig taenia by Q-adrenergic stimulants or papaverine is associated with increased concentration of cyclic AMP (cyclic adenosine-3', 5'-monophosphate) in the cells (1-5). On the other hand cyclic GMP (cyclic guanosine-3', 5'-monophosphate) is present in considerable amounts in various mammalian tissues, particularly in the gastrointesti...

We designed and built a fast scanning peripheral Hartmann-Shack (HS) wave-front sensor to measure the off-axis wave-front aberrations in the human eye. The new instrument is capable of measuring the optical quality over the central 80° horizontal visual field in 1.8 seconds with an angular resolution of 1°. The subject has an open field of view without any moving elements in the line-of-sight a...

We investigated the current reformulation of the commercially available intraocular preparation of carbachol for its effect on corneal thickness and endothelial cell ultrastructure. A 15-minute perfusion in the specular microscope with 0.01% carbachol caused a significant increase in the corneal swelling rate, which returned to control values after 75 minutes of reperfusion with Krebs Ringer bi...

I MPROVEMENT of organ preservation is essential for the success of small bowel transplantation. In the present study, canine small bowels were preserved for 24 hours in University of Wisconsin (UW). Euro-Collins (EC), or lactated Ringer's (LR) solution to evaluate which solution is appropriate. Biochemical changes in the graft during preservation and reperfusion were determined, and were compar...

y-tial intermetallic alloy have a good potential for use as biomaterial, due to its good corrosion resistance. in this paper, two fundamental electrochemical techniques namely electrochemical impedance spectroscopy and potentiodynamic anodic polarization were used to evaluate the corrosion performance of g-tial in ringer's solution. surface modification treatments were employed with the pu...

OBJECTIVES Experimental studies on sepsis have demonstrated that ethyl pyruvate is endowed with antioxidant and anti-inflammatory properties. This study aimed to investigate the effects of ethyl pyruvate on leukocyte-endothelial interactions in the mesenteric microcirculation in a live Escherichia coli-induced sepsis model in rats. METHODS Male Wistar rats were administered an intravenous sus...

While working on the heart of Rana tigrina by the perfusion method recommended by Burridge (1935), I started with a fairly concentrated solution of pure synthetic thiamin chloride in concentration of one part in 1,000 of Ringer and watched the results. No sooner the drug was perfused than the heart, which had been beating normally so far, was suddenly arrested in diastole and remained as such t...