INTRODUCTION: Dichloroacetate (DCA) is a pyruvate dehydrogenase kinase (PDK) inhibitor and is found to be an anti-cancer agent [1]. It causes the activation of pyruvate dehydrogenase (PDH) and increased glucose oxidation by promoting the influx of acetyl-CoA into the mitochondria and the Krebs cycle [1]. The hyperpolarised C experiment measures the conversion of labelled pyruvate to labelled la...

1. A lactate dehydrogenase isoenzyme present in human spermatozoa and semen was isolated and characterized biochemically in term of its pH for optimum activity and by means of K(m) values for lactate, NAD(+) and NAD analogues. The results were compared with those obtained with the human heart-type and the liver-type lactate dehydrogenase isoenzymes. 2. The enzyme was characterized by its resist...

Lactate dehydrogenase (EC 1.1.1.27) from Vibrio marinus MP-1 was purified 15-fold and ammonium activated. The optimum pH for pyruvate reduction was 7.4. Maximum lactate dehydrogenase activity occurred at 10 to 15 degrees C, and none occurred at 40 degrees C. The crude-extract enzyme was stable between 15 and 20 degrees C and lost 50% of its activity after 60 min at 45 degrees C. The partially p...

Background & Objective: Neonatal jaundice is common reason for admission in neonatal units requiring further evaluation to prevent adverse neurodevelopmental outcome. Lactate dehydrogenase levels are high hemolysis. This study was aimed explore the diagnostic properties of Dehydrogenase (LDH)in hemolytic causes hyperbilirubinemia. Methods: In this observational cross sectional study, prospe...

Schizophrenia and bipolar disorder are disorders characterized by alterations in cellular molecular mechanisms. Annexin A3 (ANXA3) has various effects on neural mechanisms membrane phospholipid function both thought to be associated with psychotic disorders. Our study consisted of 93 schizophrenia 52 healthy controls. ANXA3 was analyzed enzyme-linked immunosorbent assay (ELISA). levels were sig...

results; out of 634 patients, 61 subjects (9.62%) had significant complications including: acute renal failure, alveolar hemorrhage, ards, clotting disorders, pancreatitis, gastrointestinal bleeding and intracranial bleeding; age, jaundice, renal and pulmonary involvement (oliguria and anuria), hypotension, leukocytosis, thrombocytopenia, hyponatremia, elevated bilirubin, alanine aminotransfera...