Effects of gamma-hexachlorocyclohexane (1 X 10(-4) M) and lithium chloride (10 mM) on the cell proliferation and phosphatidylinositol metabolism of L6 myoblasts were examined. gamma-Hexachlorocyclohexane (inhibitor of phosphatidylinositol synthesis) and LiCl (inhibitor of inositol 1-phosphatase) treatment of these cells resulted in the loss of their proliferative properties. Coordinate with eff...

We imaged axons in layer (L) 1 of the mouse barrel cortex in vivo. Axons from thalamus and L2/3/5, or L6 pyramidal cells were identified based on their distinct morphologies. Their branching patterns and sizes were stable over times of months. However, axonal branches and boutons displayed cell type-specific rearrangements. Structural plasticity in thalamocortical afferents was mostly due to el...

A small series of 5-nitro-2-aminothiazole-based amides containing arylpiperazine-, biphenyl- or aryloxyphenyl groups in their core were synthesized and evaluated as antitrypanosomatid agents. All tested compounds were active or moderately active against Trypanosoma cruzi amastigotes in infected L6 cells and Trypanosoma brucei brucei, four of eleven compounds were moderately active against Leish...

Antibodies to electrolectin, a lectin endogenous to embryonic skeletal muscle, have been used to study the distribution of electrolectin during myogenesis in L6 cells and rat primary muscle cultures. Antibody binding is highest to mononucleated cells and is low to myotubes in both systems. Binding is much lower to fibroblasts in the primary cultures. Binding appears to be on the surface of thes...

AIM: ( , TC) has long been used in traditional medicine in South East Asia for the treatment of type 2 diabetes mellitus. In the present study, it was aim to investigate the effect of water-ethanol extract of (WETC) on glucose transporter (GLUT1 and GLUT4), 5'AMP-activated protein kinase (AMPKα1) and peroxisome proliferator-activated receptors (PPARγ) expression. METHODS: The activation of GLUT...

Herein we investigated the molecular mechanism of action of the citrus flavonoid, quercetin in skeletal muscle cells (L6 myotubes). Taking advantage of protein kinase inhibitors, we proved that the effect of quercetin on 2-NBDG uptake in L6 myotubes was not through insulin signaling pathway, but through adenosine monophosphate kinase (AMPK) pathway and its downstream target p38 MAPK. An increas...

In this article, we submit the description of synthesis and identification of manganese(II) complexes with pyrogenic nanosilica-immobilized (d av = 10 nm; S sp = 290 m(2)/g) hydroxyaldimine ligands [Formula: see text]: salicilaldiminopropyl (L1); 5-bromosalicilaldiminopropyl (L2); 2-hydroxynaphtaldiminopropyl (L3); 2-hydroxy-3-methoxybenzaldiminopropyl (L4); 2-hydroxy-3,5-dichloroacetophenonimi...