n unbiased photo–cross-linking approach was used to probe the “molecular path” of a growing nascent Escherichia coli inner membrane protein (IMP) from the peptidyl transferase center to the surface of the ribosome. The nascent chain was initially in proximity to the ribosomal proteins L4 and L22 and subsequently contacted L23, which is indicative of progression through the ribosome via the main...

A large theoretical literature focuses on the question: What determines Ž rms’ boundaries? Recently, Garicano and Santos and Holmstrom and Milgrom have proposed theories in which Ž rms’ boundaries re ect the division of labor across individuals. This paper discusses strategies for generating and testing empirical propositions from this emerging class of theories. We propose that variation in t...

Reports of ketolide resistance remain scarce, however, a few laboratory-derived and clinical isolates of resistant Streptococcus pneumoniae have been documented. Mutations in key telithromycin-binding sites such as domains II and V of the 23S rRNA and ribosomal proteins L4 and L22, as well as mutations of the resistance determinant erm(B) are associated with elevated telithromycin MICs. Mutatio...

In recent years, a number of mergers have occurred in the petroleum industry involving upstream firms that are imperfectly integrated into retail markets. In order to empirically evaluate the competitive effects of such mergers, this paper proposes a structural model of supply and demand that reflects divisions between upstream producers and downstream retailers. Neither downstream costs includ...

Exclusive dealing arrangements, in which a distributor contracts to work exclusively with a single manufacturer, can be efficiency enhancing or they can be an anticompetitive means to foreclose markets. This paper evaluates the effect of exclusive distribution arrangements on competition in the Chicago beer market in 1994. A diagnostic test is provided to judge whether exclusive arrangements be...

Using loan-level data from Mexico, we study the relationship between the organizational structure of banks and the terms of lending to small businesses. We find that banks with decentralized lending structures – where branch managers have autonomy over the terms of lending – give larger loans to small firms and those with more "soft information". However, decentralized banks are also more respo...

This paper presents empirical evidence that endogenous fixed costs play a central role in determining the equilibrium structure of the retail food industry. Using the framework developed in Sutton [Sutton, J. (1991). Sunk Cost and Market Structure: Price Competition, Advertising, and the Evolution of Concentration (MIT Press, Cambridge).], I construct a structural model of retail competition in...

This paper addresses the problem of the general validity of models of the industry life cycle, which have been proposed to analyse the long-term evolution of many industries, exhibiting a typical pattern of shakeout. We study a case of non shake-out in the commercial jet aero-engine industry, marked by a small number of entry events distributed over 40 years of industry evolution, by no exits a...

This paper compares outsourcing processes in France, Italy and Japan in two types of firms, large firms and also small firms. It is shown that outsourcing has increased over the last two decades in both small and large firms in all three countries and that mainly in the last decade the tendency has been to increasingly involve some of the suppliers in product development. We interpret this evid...

This paper has two goals. First, to provide an accurate characterisation of the new small firm in Scotland by reference to markets, finance, costs, business strategy, human capital, internal organisation and technical change. Second, to use these same features to discover salient differences between small firms which either survive or close, two or three years after inception. The empirical evi...