L-Tryptophan and Eosinophilia-Myalgia Syndrome Participant's Guide Learning Objectives After completing this case study, the participant should be able to: Discuss issues related to rapid establishment of national surveillance for a newly recognized and little understood disorder. Discuss development of case definitions. Describe the elements of design and the advantages and disadvantages of ca...

Melatonin is a major biosynthetic product of pineal gland exerting a potent antioxidant and the reactive oxygen metabolites scavenging activities but the mechanism of formation of this indole at extrapineal sources has not been fully elucidated. It is known that the gastrointestinal (GI)-tract plays an important role as a source of melatonin synthesis but the conversion of L-tryptophan into mel...

This paper is a report by the author of his Ph.D. Thesis. When the organism is put under exertion (load), changes in the organism result (strain). The strain is counteracted by forces mobilized in the body (stress). Stress is a physiological phenomenon. If people become ill from any type of exertion, this will, by definition be the result of strain. The (biological) changes observed in ill peop...

We describe the spectrum of clinical and histologic abnormalities of 11 women with L-tryptophan induced eosinophilia-myalgia syndrome. The illness is characterized by musculoskeletal symptoms including myalgias, arthralgias and paresthesias. The physical findings consist of muscle tenderness, neuropathies, rash, peripheral and periorbital edema. Electroneurography performed in 10 patients demon...

THE CRYSTAL STRUCTURE OF THE TITLE COMPOUND [SYSTEMATIC NAME: (2R)-3-(1H-indol-3-yl)-2-(4-nitro-1,3-dioxoisoindolin-2-yl)propanoic acid], C(19)H(13)N(3)O(6), an analogue of epigenetic modulator RG108, is constrained by strong hydrogen bonds between the indole N-H group and a carbonyl O atom of the phthalimide ring of a symmetry-related mol-ecule, and between the protonated O atom of the carboxy...

The tryptophan requirement of growing swine was determined using the oxidation of L-[1-14C]-phenylalanine as an indicator of the adequacy of the dietary tryptophan level. Forty crossbred boars (30 to 45 kg) were fed a basal diet containing 16% protein supplied by corn and gelatin. A series of experimental diets containing .05, .08, .10, .15, .20 and .25% L-tryptophan were prepared. The diets we...

This review summarizes the involvement of centrally and peripherally applied melatonin, a major hormone of pineal gland, in the mechanism of gastric mucosal integrity, gastroprotection and ulcer healing. Melatonin was originally shown to attenuate gastric mucosal lesions but the controversy exists in the literature as to whether melatonin derived from the pineal gland, considered as the major s...

The Present study summarizes the biosynthesis, characterization and optimization of auxins by Piriformospora indica and its effect on the growth of Solanum melongena L. cultivars. The biosynthesis of auxins was greatly influenced by the addition of tryptophan. Based on the data obtained from traditional one factor at a time method, optimization was carried out using the response surface methodo...

substrate. Mescaline does not inhibit the deandnation of [14C] serotonin to 5-hydroxyindoleacetic acid and has no significant effect on the intracellular content of [14C] tryptophan or its conversion to [14G] protein. It is • 14 concluded that mescaline stimulates p_ne;¢l [ C] serotonin synthesis via a primary stimula£ory action on the enzymatic conversion of [14.C]tryptophan to 5-hydroxytrypto...