L-Asparagine synthetase appears in serum approximately 7 days after the s.c. implantation of 1 X 10(5) cells of Leukemia 5178Y/AR (resistant to L-asparaginase) and increases in activity as the neoplasm grows and metastasizes. The principal source of the enzyme is the primary tumor. After intravranial inoculation of tumor, the rate of leakage of the enzyme is more pronounced than when the subcut...

1. The activity of l-asparaginase was very low in the liver of newborn rats and mice, and increased within a few days of birth. 2. In rats, but not in mice, the enzyme activity was higher in females than in males, was enhanced by administration of oestradiol, and was decreased by gonadectomy. 3. The enzyme activity decreased in mice starved or fed on a low-protein diet; in rats it was enhanced ...

Introduction: L-asparaginase and corticosteroids are widely used in the chemotherapy of acute lymphoblastic leukemia (ALL). This combination is known to cause several adverse effects one which hypertriglyceridemia. Although condition asymptomatic reversible it can lead serious complications.

Acute pancreatitis and diabetic ketoacidosis are unusual adverse events following chemotherapy based on L-asparaginase and prednisone as support treatment for acute lymphoblastic leukemia. We present the case of a 16-year-old Hispanic male patient, in remission induction therapy for acute lymphoblastic leukemia on treatment with mitoxantrone, vincristine, prednisone, and L-asparaginase. He was ...

L-asparaginases belong to a family of amidohydrolases that catalyze L-asparagine into Laspartic acid and ammonia. Although bacterial L-asparaginases have been used extensively as anti-leukemic agents, their possible role as potential drug target for pathogenic organisms has not been explored. The presence of genes coding for putative L-asparaginase enzymes in Leishmania donovani genome hinted t...