by KUMARASWAMY BUDUR, MD Objective: Major depressive disorder (MDD) is associated with sleep disturbances. An electroencephalographic (EEG) pattern of alpha wave intrusion in delta wave sleep (alpha-delta sleep) is observed in some subjects with MDD. The treatment-resistant symptoms in MDD, non-restorative sleep and fatigue, are associated with alpha-delta sleep. The objective of this study is ...

Sepsis is one of the leading causes of mortality in non-cardiac intensive care units, and the need for markers of progression and severity are high. Also, treatment of sepsis is highly debated and potential new targets of treatment are of great interest. In the previous issue of Critical Care Kumaraswamy and colleagues have investigated whether plasma apolipoprotein M (apoM) is affected during ...

the Octet platform provides analytical methods for measuring antibody and protein concentrations and binding affinities through various stages of drug discovery and development (table 1). Octet systems circumvent many limitations of ELISA and HPLc assays, enabling informed decisions to be made earlier in both drug and process development – particularly when chromatography and other critical sep...

A new family of distributions called the Kumaraswamy Rayleigh is defied and studied. Some its relevant statistical properties are derived. Many bivariate type G families using Farlie-Gumbel-Morgenstern, modified Farlie-Gumbel-Morgenstern copula, Clayton copula Renyi’s entropy The method maximum likelihood estimation used. special models based on log-logistic, exponential, Weibull, Rayleigh, Par...

Abstract In this paper, we consider Kumaraswamy-G distributions and derive a Uniformly Minimum Variance Unbiased Estimator (UMVUE) Maximum Likelihood (MLE) of the two measures reliability, namely R ( t ) = P X > Y under Type II censoring scheme sampling Bartholomew (1963). We also develop interval estimates reliability measures. A comparative study different methods point estimation has been...