Rho-associated kinase (ROCK) signaling plays a fundamental role in regulating cell morphology, adhesion, and motility. Aberrant expression of ROCK is related to tumor metastases and poor clinical outcome. Here, we show that ROCK expression is increased in metastatic human mammary tumors and breast cancer cell lines compared with nonmetastatic tumors and cell lines. Overexpression of ROCK confer...

Geologic records of Earth’s hydrosphere and meteoric precipitation older than 2 Ga are rare, although they provide insight into the past climate, rates of water-rock interaction, and intensity of plate tectonics. Here we report and describe in detail the lowest known δ18O (–16‰ to –25‰) terrestrial silicate rocks on Earth, found in Paleoproterozoic plagiogneisses from the Belomorian complex, Ka...

Gem GTPase is a member of a protein family that includes Rad, Rem and Rem2. Although until recently precious little was known about the function of Gem, recent studies have revealed that Gem may influence cell morphology by antagonising the actions of the Rho GTPase effector protein ROCK I.

rock selection in modeling and simulation studies is usually based on two techniques; routinely defined rock types and those defined by special core analysis (scal). the challenge in utilizing these two techniques is that they are frequently assumed to be the same, but in practice, static rock-types (routinely defined) are not always representative of dynamic rock-types (scal defined) in the re...

In terms of target detection and classification, scattering from exposed rock on the seafloor, (i.e., individual rocks and rock outcrops) presents some of the most difficult challenges for modern MCM and ASW sonar systems in shallow water. Work on characterizing, modeling and simulating mean levels, and other statistical measures of acoustic scattering from rocks and rock outcrops is therefore ...

A fast, quantitative image analysis technique was developed to assess potential rock weathering by bacteria. The technique is based on reduction in the surface area of rock particles and counting the relative increase in the number of small particles in ground rock slurries. This was done by recording changes in ground rock samples with an electronic image analyzing process. The slurries were p...

Strata and surface movement induced by mining under open-pit final slope is a huge 8 threat to mine safety. Physical model test is an important method to study mining-induced strata 9 and surface movement laws. Because of rock joints predominantly control rock mass deformation 10 and failure, thus physical model test leaving out of consideration of rock joints is difficult to reflect 11 the inf...

As mining and civil tunneling progresses to depth, excavation-induced seismicity and rockburst problems increase and cannot be prevented. As an important line of defense, ground control measures and burst-resistant rock support are used to prevent or minimize damage to excavations and thus to enhance workplace safety. Rock support in burst-prone ground differs from conventional rock support whe...

Many key cellular functions, such as cell motility and cellular differentiation are mediated by Rho-associated protein kinases (ROCKs). Numerous studies have been conducted to examine the ROCK signal transduction pathways involved in these motile and contractile events with the aid of pharmacological inhibitors such as Y-27632. However the molecular mechanism of action of Y-27632 has not been f...

according to the former researcher’s presented relations for flow through rock-fill porous media, the effects of physical characteristics was not studied separately. hence, due to the application of these relations, physical characteristics of porous materials effect must be investigated separately. in various constructed physical models of porous media, the effect of several variables such as ...