Groups of Swiss ICR mice were fed 1000 ppm polybrominated biphenyls (FireMaster BP-6) in rodent chow for 4, 8, 11, and 14 days. Control groups were fed standard rodent chow without FireMaster BP-6. Animals were killed at the end of each feeding period and the livers examined by electron microscopy. EM changes noted were progressive increase in size of hepatocytes, a decrease in rough endoplasmi...

4-Ipomeanol is a pulmonary toxin in cattle and rodents that is metabolically activated by cytochromes P-450 (P-450s). P-450-mediated activation of 4-ipomeanol to DNA binding metabolites was evaluated using a vaccinia virus complementary DNA expression system and an in situ DNA-binding assay. Twelve human P-450s and two rodent P-450s were expressed in human hepatoma Hep G2 cells and examined for...

Aversive agents are proposed as potential additives to rodenticides to increase selectivity to the target species. Examples of various aversive agent categories are given, including odorants, tastants, and emetics, with examples of evaluations. Tastant additives have been found that do not interfere with rodenticidal efficacy. Denatonium benzoate (commercially available as Bitrex) is an intense...

Executive functions supported by prefrontal cortical (PFC) systems provide essential control and planning mechanisms to guide goal-directed behavior. As such, age-related alterations in executive functions can mediate profound and widespread deficits on a diverse array of neurocognitive processes. Many of the critical neuroanatomical and functional characteristics of prefrontal cortex are prese...

Two major groups of desert granivores, ants and rodents, coexist as permanent residents of local desert habitats in southwestern North America. At our Sonoran Desert study site, both of the major taxa exhibited short-term increase in density when the other taxon was experimentally removed. Over the longer term, density compensation continued at a relatively constant level for rodents in the abs...

BACKGROUND There is increasing interest in developing human cell lines to be used to better understand cell biology, but also for drug screening, toxicology analysis and future cell therapy. In the endocrine pancreatic field, functional human beta cell lines are extremely scarce. On the other hand, rodent insulin producing beta cells have been generated during the past years with great success....

We conducted a long-term rodent exclosure experiment in native grass- and shrub-dominated vegetation to evaluate the importance of top-down and bottom-up controls on plant community structure in a low-productivity aridland ecosystem. Using multiple regressions and analysis of covariance, we assessed how bottom-up precipitation pulses cascade through vegetation to affect rodent populations, how ...

Abstract Objective Standard rodent sepsis models as cecal ligation and puncture (CLP) or incision (CLI) are frequently not suited experiments, mainly because they lack surgical repair, difficult to control for severity. The colon ascendens stent peritonitis model (CASP) overcomes some of these limitations. Result Here we present our modification the CASP model, where severity can be controlled ...

Alpha-chlorohydrin (EPIBLOC) introduces a new form of rodenticide the toxicant-sterilant. EPIBLOC, as a pest control product registered and used in some countries, changes the concept of chemosterilants from theoretical to practical. The active ingredient also acts as an acute toxicant in the control of rodents. It is effective on both sexes and all age groups. Alpha-chlorohydrin is rapidly abs...