Reference 1. Tõkés A-M, Kulka J, Paku S, Szik A, Páska C, Novák PK, Szilák L, Kiss A, Bögi K, Schaff Z: Claudin-1, -3 and -4 proteins and mRNA expression in benign and malignant breast lesions: a research study. Breast Cancer Res 2005, 7:R296-R305. Correction Correction: Claudin-1, -3 and -4 proteins and mRNA expression in benign and malignant breast lesions: a research study Anna-Mária Tõkés1,...

The paper analyzes the scientific data included the author's own results about the opportunities to increase the reproductive potential of female animals by application of the natural no hormonal substances and the supposed mechanisms of their action on the reproductive system. Also the new scientific data related to the discovering of the "metabolic" hormones (leptin, ghrelin) and kisspeptin/G...

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Kisspeptins, endogenous peptide ligands for GPR54, play an important role in GnRH secretion. Since in vivo administration of kisspeptins induces increased plasma LH levels, GPR54 agonists hold promise as therapeutic agents for the treatment of hormonal secretion diseases. To facilitate the design of novel potent GPR54 ligands, residues in kisspeptins that involve in the interaction with GPR54 w...

The aim of the present study was to determine if the estradiol-induced luteinizing hormone (LH) surge is influenced by the constant exposure to TAK-683, an investigational metastin/kisspeptin analog, that had been established to depress the pulsatile gonadotropin-releasing hormone (GnRH) and LH secretion in goats. Ovariectomized goats subcutaneously received TAK-683 (TAK-683 group, n=6) or vehi...