نتایج جستجو برای: keywords folic acid

تعداد نتایج: 2689101  

2016
Tian Tian Dong Bai Wen Li Guo-Wei Huang Huan Liu

Alzheimer's disease (AD) is the most common type of dementia. Amyloid-β protein (Aβ) is identified as the core protein of neuritic plaques. Aβ is generated by the sequential cleavage of the amyloid precursor protein (APP) via the APP cleaving enzyme (α-secretase, or β-secretase) and γ-secretase. Previous studies indicated that folate deficiency elevated Aβ deposition in APP/PS1 mice, and this r...

Journal: :The Journal of clinical investigation 1963
C A GORESKY H WATANABE D G JOHNS

The urinary excretion of tritiated folic acid after a single intravenous injection in man has been measured by Johns, Sperti, and Burgen (1). Plasma concentrations of the labeled compound fell sharply initially, and then more slowly. Urinary clearance in terms of the later, slowly declining plasma levels was shown, at plasma concentrations above 10 jug per L, to be independent of plasma level a...

2015
Yan Ma Chen Zhang Xiao-Bo Gao Hai-Yan Luo Yang Chen Hui-hua Li Xu Ma Cai-Ling Lu

As a nutritional factor, folic acid can prevent cardiac and neural defects during embryo development. Our previous study showed that arsenic impairs embryo development by down-regulating Dvr1/GDF1 expression in zebrafish. Here, we investigated whether folic acid could protect against arsenic-mediated embryo toxicity. We found that folic acid supplementation increases hatching and survival rates...

Journal: :The Journal of nutrition 2012
Breanne G Swayne Nathalie A Behan Andrew Williams Patrick J Stover Carole L Yauk Amanda J MacFarlane

Folate deficiency can cause chromosome damage, which could result from reduced de novo thymidylate synthesis or DNA hypomethylation. High folic acid intake has been hypothesized to inhibit folate-dependent one-carbon metabolism, which could also lead to DNA damage. A large proportion of the general population may have high folic acid intakes. In this study, 2 experiments were conducted to exami...

Journal: :Hypertension 2013
Zhiwen Li Rongwei Ye Le Zhang Hongtian Li Jianmeng Liu Aiguo Ren

Emerging evidence has suggested that folic acid-containing multivitamins may markedly reduce the risk of gestational hypertension or preeclampsia. We examined whether maternal supplementation with folic acid alone during early pregnancy can prevent the occurrence of gestational hypertension and preeclampsia. The data are from a large population-based cohort study established to evaluate the eff...

Journal: :The American journal of clinical nutrition 2010
Rima Obeid Mariz Kasoha Susanne H Kirsch Winfried Munz Wolfgang Herrmann

BACKGROUND The importance of unmetabolized folic acid in maternal and fetal blood is not known. OBJECTIVE We investigated total folate, tetrahydrofolate (THF), 5-methyltetrahydrofolate (5-MTHF), formyl-THF, 5,10-methenylTHF, and folic acid concentrations in women and in umbilical cord blood at delivery. DESIGN The study included 87 pregnant women and 29 cord blood samples, including 24 moth...

2015
Kamal Hassan

BACKGROUND Most of the folic acid sources are rich also in potassium. Patients with chronic kidney disease (CKD) usually receive a low potassium diet. We investigated the possibility of an association between low potassium diet and folic acid deficiency. METHODS In total, 128 CKD patients participated in this cross-sectional study. Sixty-four patients with CKD grades 1 and 2 were on an unrest...

Journal: :The Indian journal of medical research 2009
Hangyuan Guo Jufang Chi Yangbo Xing Ping Wang

BACKGROUND & OBJECTIVE High plasma homocysteine (Hcy) levels are known to be associated with coronary artery disease, but the precise level associated with an increased risk is yet controversial. Whether the beneficial effects of folic acid on arterial endothelial function persist over longer periods is not known. This study was carried out to assess whether folic acid supplementation could pro...

Journal: :The American journal of physiology 1999
Richard Jaszewski Ahmed Khan Fazlul H Sarkar Omer Kucuk Martin Tobi Abbas Zagnoon Ravi Dhar Joseph Kinzie Adhip P N Majumdar

Although accumulating evidence suggests a chemopreventive role for folic acid in colon cancer, the regulation of this process in unknown. We hypothesize that supplemental folic acid exerts its chemopreventive role by inhibiting mucosal hyperproliferation, an event considered to be central to the initiation of carcinogenesis in the gastrointestinal tract. The present investigation examines the e...

Journal: :Clinical and investigative medicine. Medecine clinique et experimentale 2001
E S Callender R Rickard L Miller J Rinsky-Eng

OBJECTIVES To determine whether women who have ha da pregnancy in which the fetus is affected by a neural tube defect (NTD) know of current folic acid recommendations; whether the recommendations are followed before or during the pregnancy associated with an NTD and subsequent pregnancies; and to insure that women who have had an NTD-affected pregnancy have access to proper information about NT...

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