nor unique. Every acute children's ward has its problems which are the outcome of its history and geography; all share the problem of being at the mercy of unpredictable factors and of emergency admissions. They suffer also from the problem of having to have 3 different sizes of bed or cot. I am certain that similar experiences are common in district general hospitals throughout the country. Th...

In the aerobic tricarboxylate cycle succinate is formed via oxidation of a-ketoglutarate, but anaerobically various bacteria form it via reduction of fumarate. The latter pathway was initially inferred to account for the large amounts of succinate and its derivative, propionate, produced in the fermentation of glycerol by propionic bacteria (l-4). Furthermore, fumarate was later shown to serve ...

In the title coordination polymer, {[Sm(2)(C(4)H(2)O(4))(3)(H(2)O)(6)]·6H(2)O}(n), the Sm(III) ion is nine-coordinated by four O atoms from three different maleate ligands, two O atoms from one fumarate ligand and three O atoms from three water mol-ecules. The fumarate ligand lies on an inversion center. Adjacent Sm(III) ions are bridged by the maleate and fumarate ligands, forming a layer para...

Permeabilized cells of toluene-mineralizing, sulfate-reducing strain PRTOL1 catalyzed the addition of toluene to fumarate to form benzylsuccinate under anaerobic conditions. Recent in vitro studies with two toluene-mineralizing, denitrifying bacteria demonstrated the same fumarate addition reaction and indicated that it may be the first step of anaerobic toluene degradation. This study with str...

Dimethyl fumarate is an orally bioavailable compound for the treatment of multiple sclerosis and psoriasis. A mechanism involving nuclear factor erythroid 2-like 2 activation has been proposed to account for its efficacy in multiple sclerosis. Here, we report that dimethyl fumarate inhibits expression of integrin α4 on circulating lymphocytes in experimental autoimmune encephalomyelitis mice an...

In the crystal structure of the title salt {systematic name: 4-[3-(5H-dibenz[b,f]azepin-5-yl)prop-yl]-1-(2-hy-droxy-eth-yl)piperazin-1-ium (2Z)-3-carb-oxy-prop-2-enoate}, C(23)H(30)N(3)O(+)·C(4)H(3)O(4) (-), the piperazine group in the opipramol cation is protonated at only one of the N atoms. In the cation, the dihedral angle between the two benzene rings is 53.5 (6)°. An extensive array of in...

In the title compound, C(3)H(5)N(2) (+)·C(4)H(3)O(4) (-), the dihedral angle between the imidazolium ring and the plane formed by the fumarate anion is 80.98 (6)°. In the crystal structure, inter-molecular O-H⋯O and N-H⋯O hydrogen bonds form extended chains along [100] and [01], creating a two-dimensional network.