Article abstract—Nonpharmacologic options for the treatment of epilepsy include epilepsy surgery, vagus nerve stimulation, and the ketogenic diet. The advantages and limitations of these treatment modalities have been extensively reviewed, but there is no general consensus on when each option should be considered. The authors propose an algorithm based on the type of epilepsy. Generally, nonpha...

In patients with cancer, the wasting syndrome, cachexia, is associated with caloric deficiency. Here, we describe tumor-induced alterations of the host metabolic response to caloric deficiency that cause intratumoral immune suppression. In pre-cachectic mice with transplanted colorectal cancer or autochthonous pancreatic ductal adenocarcinoma (PDA), we find that IL-6 reduces the hepatic ketogen...

The treatment of obesity and cardiovascular diseases is one of the most difficult and important challenges nowadays. Weight loss is frequently offered as a therapy and is aimed at improving some of the components of the metabolic syndrome. Among various diets, ketogenic diets, which are very low in carbohydrates and usually high in fats and/or proteins, have gained in popularity. Results regard...

The ketogenic diet has been used for the treatment of epilepsy in children for almost 100 years. Originally, it was determined that individuals with seizures found benefit from starvation; subsequently a diet was proposed which was high in fat content, the breakdown of fat for energy producing ketones and therefore mimicking starvation(1). This was subsequently found to be effective in treating...

Context: Somatic mutation theory has been considered as a potential cause for cancer. However, major inconsistencies with the gene have necessitated serious reconsideration of this assumption. According to these inconsistencies, cancer may be metabolic disorder. mitochondrial theory, substrate-level phosphorylation suggested superior oxidative in cells. Cancer therapies such ketogenic diets (KD...