نتایج جستجو برای: ketoacyl

تعداد نتایج: 610  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Xingye Yu Tiangang Liu Fayin Zhu Chaitan Khosla

Microbial fatty acid derivatives are emerging as promising alternatives to fossil fuel derived transportation fuels. Among bacterial fatty acid synthases (FAS), the Escherichia coli FAS is perhaps the most well studied, but little is known about its steady-state kinetic behavior. Here we describe the reconstitution of E. coli FAS using purified protein components and report detailed kinetic ana...

2016
Huiya Gu Robert E. Jinkerson Fiona K. Davies Lyle A. Sisson Philip E. Schneider Matthew C. Posewitz

The isolation or engineering of algal cells synthesizing high levels of medium-chain fatty acids (MCFAs) is attractive to mitigate the high clouding point of longer chain fatty acids in algal based biodiesel. To develop a more informed understanding of MCFA synthesis in photosynthetic microorganisms, we isolated several algae from Great Salt Lake and screened this collection for MCFA accumulati...

Journal: :The Journal of biological chemistry 2010
David E Cane

Since the discovery and sequencing of 6-deoxyerythronolide B synthase 20 years ago, this exceptionally large, multifunctional protein remains the paradigm for the understanding of the structure and biochemical function of modular polyketide synthases. The broad-spectrummacrolide antibiotic erythromycin is one of several hundred closely related, branched chain, polyoxygenated polyketides, many o...

Journal: :Acta Crystallographica Section F Structural Biology and Crystallization Communications 2007

Journal: :Antimicrobial agents and chemotherapy 2006
Katherine Young Hiranthi Jayasuriya John G Ondeyka Kithsiri Herath Chaowei Zhang Srinivas Kodali Andrew Galgoci Ronald Painter Vickie Brown-Driver Robert Yamamoto Lynn L Silver Yingcong Zheng Judith I Ventura Janet Sigmund Sookhee Ha Angela Basilio Francisca Vicente José Rubén Tormo Fernando Pelaez Phil Youngman Doris Cully John F Barrett Dennis Schmatz Sheo B Singh Jun Wang

Condensing enzymes are essential in type II fatty acid synthesis and are promising targets for antibacterial drug discovery. Recently, a new approach using a xylose-inducible plasmid to express antisense RNA in Staphylococcus aureus has been described; however, the actual mechanism was not delineated. In this paper, the mechanism of decreased target protein production by expression of antisense...

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