BACKGROUND Fleischer's ring is considered to be a characteristic of keratoconus, but we have seen a ring similar to Fleischer's ring in patients with secondary keratoconus, in which the cornea becomes thinner secondarily for undetermined reasons. CASES We report 6 cases of secondary keratoconus with a corneal epithelial ring similar to the Fleischer's ring pattern. OBSERVATIONS In these 6 c...

PURPOSE To describe the clinical outcome of corneal cross-linking (CXL) in a young child with keratoconus. METHODS This is a case report of a young girl with keratoconus with ophthalmologic findings and 3-year follow-up. Follow-up visits included visual acuity measurement, retinoscopy, corneal tomography, and topography. RESULTS A girl with Down syndrome was diagnosed with bilateral keratoc...

Purpose: To report a rare case of bilateral circumscribed posterior keratoconus in microcornea associated with unilateral irido-fundal coloboma. Method: A case of bilateral circumscribed posterior keratoconus associated with unilateral irido-fundal coloboma presented to us with complaints of diminution of vision in both eyes since birth. The patient had undergone renal transplant for end stage ...

INTRODUCTION Keratoconus is a relatively frequent disease leading to severe visual impairment. Existing therapies are imperfect and clinical management may benefit from improved understanding of mechanisms leading to this disease. We aim to investigate the replication of 11 single nucleotide polymorphisms (SNPs) with keratoconus. METHODS SNPs from loci previously found in association with ker...

Several surgical strategies have been proposed to improve visual function in patients with keratoconus who become contact lens intolerant1,2. In mild-tomoderate keratoconus, when the central cornea remains clear, intrastromal corneal ring segments (ICRS), and phakic intraocular lenses (PIOLs) may provide enough BSCVA, and sometimes uncorrected visual acuity (UCVA), to postpone and sometimes avo...

Purpose: Comparing the optical coherence tomography (OCT) pachymetry patterns in keratoconus suspect and normal people Methods: Thirty-two keratoconus suspects and 36 healthy eyes were selected within the age range of 20-30 yrs. Their pachymetry pattern was obtained through OCT Visante in the minimum thickness spot, upper and lower corneal difference (I-S), lower temporal, and upper nasal thick...

IMPORTANCE It is unknown whether a neurotrophic deficit or pathologic nerve morphology persists in keratoconus in the long term after corneal collagen cross-linking (CXL) treatment. Nerve pathology could impact long-term corneal status in patients with keratoconus. OBJECTIVE To determine whether CXL treatment of keratoconus results in normalization of subbasal nerve density and architecture u...

Objective: To assess sensitivity of corneal volume, asphericity, and D index in early diagnosis keratoconus. Methods: A cross-sectional analytical study, carried out between December 2018 October 2020, which analyzed the medical records 39 patients (78 eyes) diagnosed as keratoconus by a single specialist, using criteria Belin-Ambrosio Enhanced Ectasia Display. The collected data were anterior ...

PURPOSE To decipher the biological pathways involved in keratoconus pathophysiology by determining the patterns of differential gene expression between keratoconus and control corneas. METHODS RNA was extracted from surgically removed corneas of 10 keratoconus patients and from normal corneas of 10 control patients who had undergone enucleation of an eye for ocular melanoma. Several hundred t...