KERATO-CONJUNCTIVITIS sicca is the condition which follows a reduction of secretion by the main and accessory lacrimal glands, and is characterized by interpalpebral staining of the bulbar conjunctiva with rose Bengal, punctate corneal staining with punctate opacities in Bowman's zone, the presence of thick stringy mucous strands in the lower fornices, and corneal filaments, the latter being ne...

PURPOSE To investigate the presence of anti-Ro/SSA and anti-La/SSB antibodies in the tear fluid and serum of patients with Sjögren's syndrome and to evaluate the association of these autoantibodies with the severity of keratoconjunctivitis sicca. METHODS Tear fluid and serum were obtained from 28 patients with Sjögren's syndrome and 17 age matched normal control subjects. Evaluation of tear f...

PURPOSE To test the hypothesis that beneficial effects of Cyclosporin A (CsA; Sandimmune; Sandoz, Basel, Switzerland) in treating keratoconjunctivitis sicca (KCS) include an effect on the mucin-producing conjunctival goblet cells independent of CsA's effect on lacrimation. METHODS Keratoconjunctivitis sicca was induced bilaterally in six dogs after removal of orbital and nictitans lacrimal gl...

The aim of this study was to evaluate the efficacy of a hyaluronic acid containing eye drop in ameliorating ocular surface pathology and discomfort in canine keratoconjunctivitis sicca (KCS). Twenty five dogs with KCS treated with a topical carbomer (CA)-based tear replacement gel were moved to treatment with a hyaluronic acid (HA)-containing tear replacement eye drop. Dogs were subject to a fu...

The recent advances in ocular drug delivery have been successful surpassing conventional therapy, owing to its considerable limitations. This study aims develop and optimize in-situ liposomal system design once-daily liquid preparation treat Keratoconjunctivitis sicca. Liposomes of Hyaluronic acid were prepared using soya lecithin by a thin film hydration method. Eight trial formulations made k...

PURPOSE To investigate the feasibility of parotid duct transposition after tympanic neurectomy to treat severe keratoconjunctivitis sicca (KCS) in rabbits. METHODS Thirty rabbits were divided into three groups in experiment 1. One eye was operated on, and the contralateral eye served as the control. In the KCS group, the lacrimal gland, harderian gland, and nictitating membrane were removed. ...