Guillain-Barré syndrome (acute inflammatory polyneuropathy) is a rare disorder with an incidence of one to two per 100,000 per year (Kennedy et al., 1978) but it is the commonest cause of acute muscle weakness in patients under 40 years of age. The clinical diagnosis is made by finding a symmetrical motor and sensory peripheral neuropathy, commonly with cranial nerve involvement. Mechanical ven...

Objective This study aimed to determine whether there is a clinical-radiological correlation in chronic rhinosinusitis (CRS), to compare operative findings with those of computed tomography (CT) imaging, and to determine the importance of a CT score and staging in management of CRS. Methods This study is a prospective study. Adult patients meeting diagnostic criteria for CRS were prospectivel...

The Supreme Court's recent Eighth Amendment death penalty case law is in disarray, and the confusion is symptomatic of a larger problem in constitutional doctrine. In Baze v. Rees and Kennedy v. Louisiana, the Court approached the challenged state policies with vastly different levels of deference. Though the Court purported to apply longstanding Eighth Amendment tests in both cases, Baze was h...

It has been shown previously (Kennedy and Barbaro, 1953) that the amount of crystal violet adsorbed by bacteria can be measured quantitatively by either one of two procedures. One procedure involved micro-Kjeldahl analyses of bacterial cells before and after staining. The increase in total nitrogen in the stained cells represented the dye nitrogen adsorbed. The second procedure was based on mic...

During the past six years numerous studies identified histone deacetylase (HDAC) inhibitors as candidate drugs for the treatment of neurodegenerative disorders. Two major neuroprotective mechanisms of HDAC inhibitors have been identified, namely the transcriptional activation of disease-modifying genes and the correction of perturbations in histone acetylation homeostasis, which have been shown...

In the past several years, there has been a revolution in cognitive neuroscience that may soon transform the diagnosis, treatment, and rehabilitation of persons with TBI. For instance, diagnostic functional positron emission tomography has demonstrated a heterogeneity of brain states that can lead to impaired consciousness such as coma and the persistent vegetative state.2-3 Kennedy and Bakay4 ...

There has recently been much discussion about the proper analysis of Japanese comparatives (cf., e.g., Beck et al. 2004; Oda 2008; Hayashishita 2009; Kawahara 2009; Kennedy 2009). Most of the discussion in the previous literature centers around the question of whether the semantics of Japanese comparatives should be modelled on the analysis of English comparatives. Beck et al. (2004) have argue...

I. Izbudak, L. Farage, D. Bonekamp, W. Zhang, G. Bibat, S. Mori, S. Naidu, A. Horska Radiology, Jonhs Hopkins Medical Institutions, Baltimore, MD, United States, Kennedy Krieger Institute, Baltimore, MD, United States Purpose Rett Syndrome (RTT) is a neurodevelopmental X-linked disease that affects primarily girls. Clinically, these children are normal at birth and then develop progressive auti...

schizophrenia is attributable to genes, the locus of genetic defect remains elusive. Moreover, genetic investigation provides little detail, beyond suggesting that the contribution of genes is complex, probably polygenic and unlikely to be sufficient in most cases to allow expression of the syndrome (Vincente & Kennedy, 1997). Some apparently genetic effects also need explanation in a more comp...