OBJECTIVE Flash lamp pulsed dye laser (FPDL) was used in a selected group of patients with hypertrophic scars and keloids. Objective of the study was to assess the efficacy on a large number of cases. BACKGROUND DATA FPDL is a nonablative technology, typically used in vascular malformation therapy because of its specificity for hemoglobin. METHODS A total of 59 patients (33 males and 26 fem...

A keloid is one of the most frustrating clinical problems in wound healing. Keloids form following dermal injury and exhibit exuberant and indefinite growth of collagen. Many theories have been propounded in trying to explain some of the vagaries of keloids. From one of the theories, keloid scars may develop at any age; patients between 10 and 30 years of age (reproductive age) are the most aff...

1. Gage AA, Meenaghan MA, Natiella JR, Green GW Jr. Sensitivity of pigmented mucosa and skin to freezing injury. Cryobiology 1979; 16: 348 ± 361. 2. Zouboulis ChC. Principles of cutaneous cryosurgery: an update. Dermatology 1999; 198: 111 ± 117. 3. Almond-Roesler B, Zouboulis ChC. Milde Kryochirurgie zur Behandlung aktinischer Lentigines. Allergologie 1999; 21: 420 ± 421. 4. Stern RS, Dover JS,...

Dear Editor, We herein present three rare cases of penile keloids that formed after circumcision and were effectively treated with a combined modality. We also discuss their possible causes. The current complication rate for male circumcision is 2%–4%. Hematoma, edema, infection and incision dehiscence are encountered more often, while keloid formation, a common complication after skin injury o...

OBJECTIVES/HYPOTHESIS To test whether therapeutic effects of botulinum toxin A on patient- specific keloid tissue can be reproduced on the cellular level. Specifically, effects on cell proliferation and expression of growth factors and cytokines relevant for wound healing were to be tested. STUDY DESIGN Experimental study including patient specific cell cultures of keloids. METHODS Patient-...

Several skin conditions are more common in persons with skin of color, including dermatosis papulosa nigra, pseudofolliculitis barbae, acne keloidalis nuchae, and keloids. Dermatosis papulosa nigra is a common benign condition characterized by skin lesions that do not require treatment, although several options are available for removal to address cosmetic concerns. Pseudofolliculitis barbae oc...

Scar formation is a consequence of the wound healing process that occurs when body tissues are damaged by a physical injury. Hypertrophic scars and keloids are pathological scars resulting from abnormal responses to trauma and can be itchy and painful, causing serious functional and cosmetic disability. The current review will focus on the definition of hypertrophic scars, distinguishing them f...

Keloids are the physical manifestation of an exaggerated inflammatory response resulting in excess collagen deposition. The resulting fibroproliferative mass can be distressing for patients due to appearance, pruritus, and/or pain. Despite extensive research into the pathophysiology of keloid formation and the development of numerous treatments, keloids remain a challenge to treat. Even when th...

Keloids are proliferative growths of dermal collagen, usually resulting from excessive tissue response during wound healing. There is evidence that keratinocytes may promote keloidogenesis via epithelial-mesenchymal interactions. Metallothioneins (MTs) are known to be involved in the fundamental cellular processes of growth and apoptosis. In this study, we evaluated the expression of MT isoform...

Objectives: The umbilicus is often used as a port insertion site during laparoscopic surgery because the wound invisible after surgery. However, its concave shape makes postoperative treatment difficult, resulting in umbilical keloids due to infection. Current study reports four cases of excision with satisfactory results following full-thickness skin grafts and radiation therapy.