The analysis of next-generation sequence (NGS) data is often a fragmented step-wise process. For example, multiple pieces of software are typically needed to map NGS reads, extract variant sites, and construct a DNA sequence matrix containing only single nucleotide polymorphisms (i.e., a SNP matrix) for a set of individuals. The management and chaining of these software pieces and their outputs...

Culex pipiens L., 1758 (Diptera: Culicidae) dünyadaki en önemli ve hastalık vektörü olan türlerden biridir. Efektif bir kontrol yapılabilmesi için insektisitlere karşı gelişen direnci takip etmek büyük öneme sahiptir. Bu çalışmada Türkiye Orta Doğu Karadeniz Bölgesi’nde 2020 aktif sezonunda dokuz ilden toplanan Cx. örneklerinde vgsc (kdr L1014F/C) ace-1 (G119S, F290V) spesifik bölgelerinde dire...

Although traditional Chinese medicine is effective and safe for the treatment of angiogenesis, in vivo intervention mechanism diverse, complex, largely unknown. Therefore, we aimed to explore active ingredients their mechanisms action against angiogenesis. Data on angiogenesis-related targets were collected from GeneCards, Therapeutic Target Database, Online Mendelian Inheritance Man, DrugBank,...

Vascular endothelial growth factor (VEGF) has been proposed to be among the candidate factors with the most potential to play a role in ischemia-induced collateral vessel formation. Recently, we found that VEGF activated the mitogen-activated protein kinase cascade in cultured rat cardiac myocytes. To elucidate how VEGF affects adhesive interaction of cardiac myocytes with the extracellular mat...

Voltage-gated sodium channels are the presumed site of action of pyrethroid insecticides and DDT. We screened several mutant sodium channel Drosophila lines for resistance to type I pyrethroids. In insecticidal bioassays the para(74) and para(DN7) fly lines showed greater than 4-fold resistance to allethrin relative to the allethrin sensitive Canton-S control line. The amino acid substitutions ...