C hertow and colleagues (1) have an interesting and provocative paper in this issue of JASN that brings a pragmatic approach to bear on the issue of defining acute renal failure. This area is rapidly gaining prominence and was the theme of one of the American Society of Nephrology’s research focus groups last spring. In that meeting, the terminology “acute kidney injury” (AKI) was put forth as ...

The story of alkaline phosphatase in the management of mineral and bone disorder (MBD) in patients with chronic kidney disease (CKD) is an interesting and educational part of the history of nephrology. Circulating alkaline phosphatase, a marker of bone turnover, was among the first bone markers used for the detection and management of ‘renal osteodystrophy’, a term previously used by clinicians...

Chronic kidney disease (CKD) is a public health challenge, as it has prevalence of 11% and the 14th-leading cause death worldwide (12.2 deaths per 100,000 people). Since 1990, from CKD have increased at higher rate than for any other except complications HIV infection.1Webster A.C. Nagler E.V. Morton R.L. et al.Chronic disease.Lancet. 2017; 389: 1238-1252Abstract Full Text PDF PubMed Scopus (10...

Related Article, p. 23 There is new hope on the horizon for more randomized trials in patients with kidney disease. The moving into foreground of clinical research and advanced disease are no longer systematically excluded from prospective cardiovascular outcome as they have been past.1Palmer S.C. Sciancalepore M. Strippoli G.F.M. Trial quality nephrology: how we measuring up?.Am J Kidney Dis. ...

Sodium and water are the main determinants of body volume status BP. Because sodium excreted by kidneys, maintenance homeostasis is particularly challenging in hemodialysis (HD) patients. Various interventions have been proposed to avoid fluid accumulation HD patients, including restriction dietary intake, ultrafiltration reach dry weight, increased plasma dialysate concentration ([Na+]D) gradi...

In a groundbreaking meeting, leading global kidney disease organizations came together in the fall of 2020 as an International Home Dialysis Roundtable (IHDR) to address strategies increase access and uptake home dialysis, both peritoneal dialysis hemodialysis. This challenge has become urgent wake coronavirus 2019 (COVID-19) pandemic, during which patients with advanced disease, who are more s...

Bone and mineral metabolism becomes dysregulated with progression of chronic kidney disease (CKD), increasing levels parathyroid hormone serve as an adaptive response to maintain normal phosphorus calcium levels. In end-stage renal disease, this maladaptive high may occur. We summarize strategies control hyperphosphatemia based on a systematic literature review clinical trial real-world observa...

Wireless communication is an important and critical issue for the micropump system for implantable drug delivery applications. For satisfying different installation requirements, the flexible circuit board is much suitable for different outer shape. As such, this paper provides a wireless implantable micropump system by flexible printed circuit board (FPCB). For normal electronic circuit design...