Abstract MOGNO is the micro and nano tomography dedicated beamline at Sirius, operating three specific energies: 21.5, 39.0, 67.7 keV. Its optics composed by a set of mirrors (pre-KB + KB set), delivering 3 mrad cone beam, coming from 100x100 nm 2 main source. The pre-KB mirror must be aligned to produce secondary source 0.3 x 800.0 µm , however, such an alignment challenging, as deviations it ...

Nuclear factor-kB (NF-kB) is a family of highly regulated dimeric transcription factors that play pivotal roles in inflammatory responses and immunological reactions. Although they are often activated concurrently, classical and alternative NF-kB activation pathways have distinct regulatory functions, producing secondary inflammatory responses and regulating lymphoid organ development, respecti...

This paper describes extensions of the 4 kb/s hybrid MELP/CELP coder, up to 6.4 kb/s and down to 2.4 kb/s. The baseline 4 kb/s coder uses three coding modes: MELP in strongly voiced speech frames, CELP with pitch prediction in weakly voiced frames, and CELP with stochastic excitation in unvoiced frames. To minimize switching artifacts between parametric MELP and waveform CELP coding, an alignme...

In this study we investigated the effect of NF-kB signaling blockade on polymethylmethacrylate (PMMA) particle-induced osteoclastogenesis in vitro. We first established effective blockade of NF-kB activity as tested by electrophoretic mobility shift assays (EMSA). Particle-induced NF-kB activation in murine osteoclast precursor cells (CSF-1-dependent bone marrow macrophages) was markedly reduce...

In order to investigate the malignant phenotype of cyclooxygenase (COX)-2 overexpressing cancer cells, a human epidermoid KB carcinoma cell line minimally expressing COX-2 protein was transfected with human COX-2 cDNA. In this study, we used a COX-2 transfected clone KB/COX-2 and a neomycin-transfected clone KB/neo as the control. When we examined the susceptibility to anticancer agents, there ...

Previous studies addressing functional aspects of nuclear factor KB (NF-KB) activation in normal and transformed keratinocytes revealed complex and seemingly contradictory roles of this transcription factor in this cell type. In normal skin, NF-KB signaling seems to inhibit squamous cell carcinoma development whereas, in squamous cell carcinoma themselves, deregulated NF-KB expression and/or si...

In this study, we used plasmid profile analysis, XbaI macrorestriction with pulsed-field gel electrophoresis (PFGE), and PCR of the ipaH gene, to study the molecular characteristics of 183 Shigella spp. isolated during May 2000 to April 2003 from rectal swabs of patients with watery and/or bloody diarrhoea in a new industrialized area of Thailand. Among the 183 isolates, 167 were S. sonnei and ...

Gukovsky, Ilya, Anna S. Gukovskaya, Thane A. Blinman, Vjekoslav Zaninovic, and Stephen J. Pandol. Early NF-kB activation is associated with hormone-induced pancreatitis. Am. J. Physiol. 275 (Gastrointest. Liver Physiol. 38): G1402–G1414, 1998.—Inflammation and cell death are critical to pathogenesis of acute pancreatitis. Here we show that transcription factor nuclear factor-kB (NF-kB), which r...

The Zarankiewicz number z(b; s) is the maximum size of a subgraph of Kb,b which does not contain Ks,s as a subgraph. The two-color bipartite Ramsey number b(s, t) is the smallest integer b such that any coloring of the edges of Kb,b with two colors contains a Ks,s in the rst color or a Kt,t in the second color.In this work, we design and exploit a computational method for bounding and computing...