The biochemical landscape of lysine acetylation has expanded from a small number of proteins in the nucleus to a multitude of proteins in the cytoplasm. Since the first report confirming acetylation of the tumor suppressor protein p53 by a lysine acetyltransferase (KAT), there has been a surge in the identification of new, non-histone targets of KATs. Added to the known substrates of KATs are m...

Catalases are widely used in many scientific areas. A catalase gene (Kat) from Geobacillus sp. CHB1 encoding a monofunctional catalase was cloned and recombinant expressed in Escherichia coli (E. coli), which was the first time to clone and express this type of catalase of genus Geobacillus strains as far as we know. This Kat gene was 1,467 bp in length and encoded a catalase with 488 amino aci...

We describe a clinical decision support system (CDSS) designed to provide timely information germane to poisoning. The CDSS aids medical decision making through recommendations to clinicians for immediate evaluation. The system is implemented as a rule-based expert system with two major components: the knowledge base and the inference engine. The knowledge base serves as the database which cont...

The levels of kynurenic acid (KYNA), an astrocyte-derived metabolite of the branched kynurenine pathway (KP) of tryptophan degradation and antagonist of α7 nicotinic acetylcholine and N-methyl-D-aspartate receptors, are elevated in the prefrontal cortex (PFC) of individuals with schizophrenia (SZ). Because endogenous KYNA modulates extracellular glutamate and acetylcholine levels in the PFC, th...

Elevation of the interstitial fluid pressure (IFP) of carcinoma is an obstacle in treatment of tumors by chemotherapy and correlates with poor drug uptake. Previous studies have shown that treatment with inhibitors of platelet-derived growth factor (PDGF) or vascular endothelial growth factor (VEGF) signaling lowers the IFP of tumors and improve chemotherapy. In this study, we investigated whet...

Bu çal??ma, acil uzaktan ö?retimde s?n?f ö?retmenlerinin COVID-19 salg?n? sürecindeki tecrübelerinin ve görü?lerinin incelemesini kapsamaktad?r. Ara?t?rma, zincir okullardan birine ait bir kampüste, 10 ö?retmeninden veriler toplanarak gerçekle?mi?tir. Ara?t?rma nitel ara?t?rma türünün fenomenoloji deseni ile desenlenmi?tir. Veri toplama 3 a?amada ?lk olarak haz?rbulunu?luklar?n? ölçmek amaçl? k...

Two opposing enzyme classes regulate fundamental elements of genome maintenance, gene regulation and metabolism, either through addition of an acetyl moiety by histone acetyltransferases (HATs) or its removal by histone de-acetyltransferases (HDAC), and are exciting targets for drug development. Importantly, dysfunctional acetylation has been implicated in numerous diseases, including cancer. W...

The Copying Approach to Tabling, abbrv. CAT, is an alternative to SLG-WAM and based on total copying of the areas that SLG-WAM freezes to preserve execution states of suspended computations. The disadvantage of CAT as pointed out in a previous paper is that in the worst case, CAT must copy so much that it becomes arbitrarily worse than SLG-WAM. Remedies to this problem have been studied, but a ...