Dehydrosoyasaponin-I (DHS-I) is a potent activator of high-conductance, calcium-activated potassium (maxi-K) channels. Interaction of DHS-I with maxi-K channels from bovine aortic smooth muscle was studied after incorporating single channels into planar lipid bilayers. Nanomolar amounts of intracellular DHS-I caused the appearance of discrete episodes of high channel open probability interrupte...

Inhibitors of PDZ-peptide interactions have important implications in a variety of biological processes including treatment of cancer and Parkinson's disease. Even though experimental studies have reported characterization of peptidomimetic inhibitors of PDZ-peptide interactions, the binding modes for most of them have not been characterized by structural studies. In this study we have attempte...

We present new results on the related rare K L decay modes K 0 L ! + and K L ! + ee . KTeV has performed the rst direct measurement of the form factor for the \direct emission" component of K L ! + decays, a quantity with rami cations for particular chiral models. In addition, the form factor and direct emission/inner bremsstrahlung branching ratio | also presented here | are important input pa...

The dynamical properties of strongly coupled charged-particle bilayers are investigated by molecular dynamics (MD) simulation and theoretical analysis. The spectra of the current correlation functions show the existence of two (in-phase and out-of-phase) longitudinal and two (in-phase and out-of-phase) transverse collective modes. The out-of-phase modes possess finite frequencies at wave number...

Single 4,7,12,15-tetrakis[2.2]paracyclophane were deposited on NiAl(110) surface at 11 K. Two adsorbed species with large and small conductivities were detected by the scanning tunneling microscope (STM). Their vibrational properties were investigated by inelastic electron tunneling spectroscopy (IETS) with the STM. Five vibrational modes were observed for the species with the larger conductivi...

We use boundary string field theory to study open string tachyon condensation on a three-sphere closed string background. We consider the closed string background described by SU(2)k WZW model in the limit of large k. We compute the exact tachyon potential and analyse the decay modes.

We present an overview of rare K, D and B decays. Particular attention is devoted to those flavour-changing neutral-current processes of K and B mesons that offer the possibility of new significant tests of the Standard Model. The sensitivity of these modes to physics beyond the Standard Model and the status of their experimental study are also discussed.

For any controllable linear system it is clear that the minimum control energy must increase unboundedly as the available time for exact control decreases to 0. This is made precise, obtaining asymptotically O(T−(K+1/2) behavior for the norm of the control operator where K is the order of the ‘least controllable’ modes (the minimal exponent for the rank condition).