Abstract Assembled amyloid beta (Aβ) peptides have been considered pathological assemblies involved in human brain diseases, and the electron transfer or transport characteristics of Aβ are important for formation structured assemblies. Here, we report electrical surface-assembled similar to those observed Alzheimer’s patients. These correlate their characteristics. Electrical current–voltage p...

Series arrays of closely spaced, planar long Josephson junctions were demonstrated to be transducers magnetic flux featuring high-dynamic range, wide-bandwidth, and the capability operate at cryogenic nitrogen temperatures. By tuning scaling geometry these devices, it is possible improve their sensitivity an applied field generate higher voltage responses. Moreover, devices feature linear respo...

We study the switching characteristics of nanoscale junctions created between a tungsten tip and a silver film covered by a thin ionic conductor layer. Atomic-sized junctions show spectacular current induced switching characteristics, but both the magnitude of the switching voltage and the direction of the switching vary randomly for different junctions. In contrast, somewhat larger junctions w...

Junctions form critical features in motion segmentation, image enhancement, and object classification to name but a few application domains. Traditional approaches to identifying junctions include convolutional methods, which involve considerable tuning to handle non-trivial inputs and diffusion techniques that address only symmetric structure. A new approach is proposed that requires minimal t...

Introduction Hematopoiesis in mouse fetal liver starts at 10 days of gestation and begins to decline after 15 days of gestation [1]. During postnatal hematopoietic involution, hepatocyte volume rapidly increases, and four types of specialized junctions; i.e., adherens junctions, desmosomes, tight junctions and gap junctions, appear to be fully developed in liver cells [2]. Neonatal livers exami...

This review highlights the contribution of gap junctions to the pathophysiology of epilepsy. The tissue expression and spatiotemporal regulation of connexins is discussed, and the phenotypes of specific connexin knockouts are considered. Electrophysiologic studies have implicated gap junctions in the generation of very fast oscillations preceding seizures. Gap junction inhibitors have shown pow...

Gap junctions are highly conductive channels that allow the direct transfer of intracellular messengers such as Ca2+ and inositol triphosphate (IP3) between interconnected cells. In brain, astrocytes are coupled extensively by gap junctions. We found here that gap junctions among astrocytes in acutely prepared brain slices as well as in culture remained open during ischemic conditions. Uncoupli...

Fibrin molecules polymerize to double-stranded fibrils by intermolecular end-to-middle domain pairing of complementary polymerization sites, accompanied by fibril branching to form a clot network. Mass/length measurements on scanning transmission electron microscopic images of fibrils comprising branch points showed two types of junctions. Tetramolecular junctions occur when two fibrils converg...