To evaluate the role of sexually dimorphic tissue expression of 11beta-oxidase activity of 11beta-hydroxysteroid dehydrogenase (11betaHSD) in gender-associated blood pressure differences, we have studied female and male hypertensive rats of two different strains and their normotensive controls: spontaneously hypertensive rats (SHR), Wistar-Kyoto rats (WKY) and Dahl salt-sensitive (SS/Jr) and sa...

To evaluate current perioperative antithrombotic management in neuroendovascular therapy in Japan, we analyzed perioperative anticoagulant and antiplatelet use in various procedures and examined their relationships with periprocedural adverse events. Patient’s data from nationwide surveys administered by the Japanese Registry of Neuroendovascular Therapy (JR-NET) between January 2005 and Decemb...

The paper studies the eigenvalue distribution of Schur complements of some special matrices, including nonstrictly diagonally dominant matrices and general H−matrices. Zhang, Xu, and Li [Theorem 4.1, The eigenvalue distribution on Schur complements of H-matrices. Linear Algebra Appl., 422:250–264, 2007] gave a condition for an n×n diagonally dominant matrix A to have |JR+(A)| eigenvalues with p...

In multiwinner approval voting, the goal is to select k-member committees based on voters' ballots. A well-studied concept of proportionality in this context justified representation (JR) axiom, which demands that no large cohesive group voters remains unrepresented. However, JR axiom may conflict with other desiderata, such as coverage (maximizing number who approve at least one committee memb...

EDITORIAL " World Psychiatry " : an opportunity for psychiatrists 1 of the world J.J. LÓPEZ-IBOR JR. The WPA and the fight against stigma 30 because of mental diseases J.J. LÓPEZ-IBOR JR.

Development of a vaccine for HIV-1 requires a detailed understanding of the neutralizing antibody responses that can be experimentally elicited to difficult-to-neutralize primary isolates. Rabbits were immunized with the gp120 subunit of HIV-1 JR-CSF envelope (Env) using a DNA-prime protein-boost regimen. We analyzed five sera that showed potent autologous neutralizing activity (IC50s at ∼10(3)...

We have reported that cytochrome P-450-dependent omega-hydroxylation of arachidonic acid is reduced in microsomes prepared from the renal outer medulla of Dahl salt-sensitive (SS/Jr) rats, but the functional significance of this observation is unknown. The present study examined whether long-term induction of renal fatty acid omega-hydroxylase with clofibrate would alter the development of hype...

30. Spann JR Jr, Mason DT, Zelis RF: The altered performance of the hypertrophied and failing heart. Am J Med Sci 258: 291, 1969 31. Mehmel HC, Mazzoni S, Krayenbuehl HP: Contractility of the hypertrophied human left ventricle in chronic pressure and volume overload. Am Heart J 90: 236, 1975 32. Williams JF Jr, Potter RD: Normal contractile state of hypertrophied myocardium after pulmonary arte...

In the inbred Dahl salt-sensitive rat (SS/Jr strain), it has been proposed that a T for A transversion in the DNA sequence encoding amino acid 276 in the «1 subunit isofonn of Na,K-ATPase may impair ion transport and contribute to the pathogenesis of hypertension. This hypothesis is of major scientific interest because it represents the first attempt to explain the pathogenesis of salt-sensitiv...