Diabetic nephropathy (DN) remains the most common cause for end stage renal disease (ESRD) as the burden of diabetes increases worldwide [13]. The mechanisms of DN are not very clear, but the extensive investigation has documented the key role of the rennin angiotensin aldosterone system (RAAS) in the pathogenesis and pathophysiology of DN [4]. Accordingly, blockade of the RAAS is first-line th...

RESULTS: The total number of eosinophils was significantly increased in the group of asthma patients versus second and third group. We found that the presence of ECP demonstrate an ongoing inflammation, with or without clinical symptoms of asthma patients. There was significant difference between the values of ECP of asthma patients versus second and third group. Our results have shown that IL-...

Over the past 20 years, the requested informations for drugs safety and efficacy are expanded with data about patient results, cost and cost-effectiveness, which increased significantly the соsts of pharmaceutical companies. Direct comparisons must be carried out with other drug product and these pharmacoeconomic comparisons are called Phase IV or post-marketing studies. Cost analysis focuses o...

In the presented case report, we evaluated the mechanism of the external iliac, the common femoral and the superficial femoral arterial thrombosis secondary to total hip arthroplasty. A 75year-old female sufferd from 5.5 cm shorter left lower limb and same sade coxarthritis. Next day after arthroplasty and eqalisation of the lower limbs, an acute ishemia of the treated leg was presented. Multys...

Results: Pearson’s correlation indicated a significant positive association between changes in NC and changes in body mass index and WC in both men and women. ROC analysis showed that the area under the curve (AUC) for NC and BMI >25 kg/m2 was 0.80 for men, 0.69 for women, respectively, while that for BMI>30 kg/m2 was 0.88 for men, 0.75 for women, respectively. NC ≥ 38 cm for men and ≥ 36 cm fo...

MATERIAL AND METHODS: We performed a cross-sectional study including 37 never-smoking male workers employed in parquet manufacture and an equal number of never-smoking male office workers studied as a control. Evaluation of examined subjects included completion of a questionnaire for respiratory symptoms in the last 12 months and baseline spirometry performed according to the actual recommendat...

Food-dependent exercise-induced anaphylaxis (FDEIA), is a severe form of allergy for which the ingestion of a specific food, usually before physical exercise induces symptoms of anaphylaxis. Patients typically have IgE antibodies to the food that triggers the reactions; however, the symptoms appear only if the co-factors act together. The most common reported cause of these reactions seems to b...