OBJECTIVE Juvenile idiopathic arthritis (JIA) is a chronic rheumatic disease of childhood. Two well-established genetic factors known to contribute to JIA susceptibility, HLA and PTPN22, account for less than half of the genetic susceptibility to disease; therefore, additional genetic factors have yet to be identified. The purpose of this study was to perform a systematic search of the genome t...

In arthritis patients, diagnosis can be delayed further because symptoms of the underlying disease might mimic complaints caused by the fracture. In this report, we present two JIA patients with stress fractures. A 10-yr-old girl with polyarticular JIA and a 14-yr-old boy with systemic onset of JIA presented with complaints of pain, the boy in the left extremity and the girl in both lower extre...

Background Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatological disease with an incidence of 1 in 1000. Methotrexate is the primary DMARD given to patients with JIA but approximately 30% of children fail to respond. The SPARKS CHARM study enrolls patients with JIA about to start MTX with the aim to discover predictors of response to MTX, to distinguish patients who w...

BACKGROUND Juvenile idiopathic arthritis (JIA) is considered to be an autoimmune disease, but the etiology is unknown. We decided to study the influence of early nutrition on later development of JIA. METHODS All parents with children born between October 1, 1997 and October 1, 1999 in Southeast Sweden were asked to participate in the ABIS prospective cohort study (All Babies in Southeast Swe...

Preventing the development of antibiotic resistance is 1 of the primary goals of antimicrobial stewardship. The overuse of antibiotics directly contributes to the development of resistant pathogens, and the emergence of bacterial resistance is a public health threat associated with significant morbidity and mortality. However, bacterial resistance is not the only unintended consequence of antib...

BACKGROUND Juvenile Idiopathic Arthritis (JIA) is the most common cause of non-infectious joint inflammation in children. Synovial inflammation results in pain, swelling and stiffness. Animal and adult human studies indicate that localized joint-associated inflammation may produce generalized changes in pain sensitivity. The aim was to characterize pain sensitivity in children with JIA to mecha...

OBJECTIVE To identify differences in peripheral blood gene expression between patients with different subclasses of juvenile idiopathic arthritis (JIA) and healthy controls in a multicenter study of patients with recent-onset JIA prior to treatment with disease-modifying antirheumatic drugs (DMARDs) or biologic agents. METHODS Peripheral blood mononuclear cells (PBMCs) from 59 healthy childre...

We read with great interest the article by Heijstek et al regarding the safety of the bivalent human papillomavirus (HPV) vaccine in patients with juvenile idiopathic arthritis ( JIA). Their prospective controlled observational cohort study of 68 patients revealed no differences in adverse events between female JIA patients and healthy girls. The authors concluded that the vaccine is well toler...

BACKGROUND The use of complementary alternative medicine (CAM) is potentially prevalent among paediatric patients with chronic diseases but with variable rates among different age groups, diseases and countries. There are no recent reports on CAM use among paediatric patients with inflammatory bowel disease (IBD) and juvenile idiopathic arthritis (JIA) in Europe. We hypothesized that CAM use as...

PurposeTo assess the long-term outcome of uveitis in juvenile idiopathic arthritis (JIA).DesignPopulation-based, multicenter, prospective JIA cohort, with a cross-sectional assessment JIA-associated (JIA-U) 18 years after onset JIA.ParticipantsA total 434 patients JIA, whom 96 had uveitis, from defined geographic areas Denmark, Finland, Norway, and Sweden.MethodsPatients between January 1997 Ju...