background: suicide is a problem worldwide and occupation is an important risk factor. in the last decade, 55 200 deaths in the us were attributed to occupational risk factors. objective: to determine if toxic metal exposure was associated with suicide risk among paducah gaseous diffusion plant (pgdp) workers. methods: we assembled a cohort of 6820 nuclear industry workers employed from 1952 to...

The Rockefeller University Press $30.00 J. Exp. Med. Vol. 206 No. 5 968-969 www.jem.org/cgi/doi/10.1084/jem.20090867 968 One mouse ≠ one experiment In the past several years, the editors of the JEM have noticed a troubling trend. Authors are increasingly submitting data for publication that derive from a single experiment. Whatever the driving force behind this trend, it is a worrying one. The ...

Abstract Tunisia is known of sparse and moderate earthquakes. However, there are seismically damaged historical buildings in the eastern Sahel region. The Roman amphitheatre Thysdrus (modern El-Jem), various Islamic religious secular Sousse Monastir testify to seismic events with intensity up IX (EMS98 scale). We raise hypothesis that their destruction was caused by nearby east-west Cherichira-...

The origin of ultra-high energy cosmic rays is discussed in light of the latest observational results from the Pierre Auger Observatory, highlighting potential astrophysical sources such as active galactic nuclei, gamma-ray bursts, and clusters of galaxies. Key issues include their energy budget, the acceleration and escape of protons and nuclei, and their propagation in extragalactic radiation...

Two tools addressing different aspects of educational mathematical documents have been developed in our research group and presented to the JEM community on previous occasions: SWiM is a semantic wiki for collaborating on such documents, and JOBAD is a framework that allows for reading documents interactively. In this paper, we outline a vision of an integrated educational environment for inter...

© 2008 Weller et al. The Rockefeller University Press $30.00 J. Exp. Med. Vol. 205 No. 6 1331-1342 www.jem.org/cgi/doi/10.1084/jem.20071555 1331 In humans, peripheral blood B cells expressing the CD27 marker and mutated Ig receptors are usually considered to be memory B cells generated in germinal centers (GCs) during immune responses to T-dependent (TD) antigens. In adults, approximately half ...