ADRs: adverse drug reactions LTT: lymphocyte transformation test MDH: multiple drug hypersensitivity MDHS: multiple drug hypersensitivity syndrome MP: Mycoplasma pneumoniae PA: particle agglutination SJS/TEN: Stevens-Johnson syndrome/toxic epidermal necrolysis Tregs: regulatory T cells INTRODUCTION Many adverse drug reactions (ADRs), including Stevens-Johnson syndrome (SJS)/toxic epidermal necr...

Methods: A retrospective chart review from January 1998 to May 2011 identified 128 SJS/TEN patients admitted to Loyola University Medical Center Burn intensive care unit. The degree of initial ocular surface inflammation was graded as mild, moderate, or severe within the first 2 weeks of admission. Patients were managed either medically or with amniotic membrane (AM). Outcomes were graded as go...

Background / Objective Prior use of “lymphocyte transformation test” (LTT) suggested that it was less often positive in Stevens-Johnson syndrome (SJS), Toxic Epidermal Necrolysis (TEN), than in other cutaneous reactions, with possible dependence on sampling date. We explored the possible role of inhibitory co-receptors in LTT, using well-defined groups of patients who reacted to carbamazepine (...

The Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening allergic reactions to medication. They require immediate treatment with the primary goal to prevent infection and encourage healing. This research proposes a specific treatment and care for SJS/TEN patient using sterile banana leaf dressing, which allows the patient to be discharged swiftly and reduces ...

Epidemiologic Characteristics Daniel Olson, MD; Louise Francois Watkins, MD, MPH; Alicia Demirjian, MD, MMSc; Xia Lin, PhD, MSPH; Christine C. Robinson, PhD; Mary Glode, MD, FIDSA; Preeta Kutty, MD; Samuel R. Dominguez, MD, PhD; Pediatric Infectious Diseases, University of Colorado Denver, Aurora, CO; Centers for Disease Control and Prevention, Atlanta, GA; Children’s Hospital Colorado, Denver,...

BACKGROUND Adverse cutaneous drug reactions (ACDRs) are the most commonly reported adverse drug events. The causative drugs and clinical patterns of ACDRs are different in various populations. This study was conducted to identify the clinical patterns, causative drugs and reasons for drug administration in patients hospitalized due to ACDR. MATERIALS AND METHODS This retrospective study was c...

Investor sophistication has lagged behind the growing complexity of retail financial markets. To explore this, we develop a dynamic model to study the interaction between obfuscation and investor sophistication in mutual fund markets. Taking into account different learning mechanisms within the investor population, we characterize the optimal timing of obfuscation for financial institutions who...

BACKGROUND Antituberculosis (anti-TB) drug allergy often involves multiple concurrently administered drugs which subsequently need to be reinitiated as no better alternatives exist. OBJECTIVE To describe the results of tailored sequential desensitization-rechallenge (D-R) for anti-TB drug allergy. METHODS Consecutive patients who had undergone D-R to anti-TB drugs between 1 September 1997 a...

PURPOSE To verify the hypothesis that protein concentrations, such as lactoferrin, epidermal growth factor (EGF), and aquaporin 5 (AQP5), in tears are abnormal in patients with dry eye. DESIGN Prospective case-control study. METHODS One hundred three dry eye patients were divided into three groups: dry eye not associated with the Sjögren syndrome (non-SS; n = 71), Sjögren syndrome (SS; n = ...