Based on clinical and pathological observation Creutzfeldt-Jakob disease (CJD) been classified into three groups: (1) Familial: (2) Iatrogenic: (3) Sporadic: Shortly after the appearance of bovine spongiform encephalopathy (BSE), CJD a disease normally seen in older patients was identified in young patients with non-classical presentation. It now appears that patients all age groups have died o...

A patient with rapidly progressive cognitive decline over an approximately four month period was suspected to have sporadic Creutzfeldt-Jakob disease. Features thought to support this diagnosis included psychiatric symptoms (anxiety and depression), visual hallucinations and a visual field defect. However, the finding of papilloedema broadened the differential diagnosis. Although standard brain...

A patient is described who showed subacute dementia and ataxia and, finally, acute asending polyradiculoneuritis. At necropsy, together with the cerebral and cerebellar lesions that are typical of Creutzfeldt-Jakob disease, the lesions of the spinal motor neurons, the spinal ganglia, and of the roots and peripheral nerves were analogous with those of the Guillain-Barré-Landry syndrome. The aeti...