ABSTRACT The objective of the study was to evaluate antiparasitic resistance against horse nematodes in South Rio Grande do Sul, Brazil. results concerning tests anthelmintic efficacy on horses, stored database Parasitic Diseases Study Group (GEEP) - Veterinary Faculty, at Federal University Pelotas (UFPel), were carried out laboratory from 2018 2019. Stool samples received farms with breeding ...

Vector control/killing has been a long and durable strategy for malaria control across the globe. Current efforts to kill or dramatically shorten the life span of female Anopheles mosquitoes have honed the use of insecticides to specifically meet the biology of mosquito biting and resting behaviors, including putting insecticide on long-lasting insecticidal nets (LLINs) where the mosquito lands...

Objective: To determine the efficacy and safety of oral ivermectin topical permethrin when given either alone or in combination patients with scabies. Study Design: Randomized Controlled Trial. Setting: Department Dermatology, Sheikh Zayed Hospital, Lahore. Period: April, 2022 to September, 2022. Material & Methods: A total 369 scabies, age 18-60 years both genders were enrolled after takin...

Ivermectin is a pivotal drug for the control of onchocerciasis and lymphatic filariasis, which is increasingly identified as a useful drug for the control of other Neglected Tropical Diseases. Its role in the treatment of soil transmitted helminthiasis through improved efficacy against Trichuris trichiura in combination with other anthelmintics might accelerate the progress towards breaking tra...

BACKGROUND Ivermectin (Mectizan, Merck and CO. Inc.) is being widely used in the control of human onchocerciasis (Onchoverca volvulus) because of its potent effect on microfilariae. Human studies have suggested that, at the standard dose of 150 microg/kg an annual treatment schedule of ivermectin reversibly interferes with female worm fertility but is not macrofilaricidal. Because of the import...

BACKGROUND Infection with the filarial nematode Onchocerca volvulus can lead to severe dermatitis, visual impairment, and ultimately blindness. Since the currently used drug, ivermectin does not have macrofilaricidal or strong permanent sterilising effects on the adult worm, more effective drugs are needed to complement the use of ivermectin alone. Wolbachia endosymbiotic bacteria in filariae h...

The performance and 'drop-out' rates of ivermectin (Mectizan) distributors in the Ugandan programme for community-directed treatment with ivermectin (CDTI) were investigated and related to the manner in which the distributors were recruited. Distributors, from randomly selected communities endemic for onchocerciasis in seven of the 10 affected districts, were interviewed. Questionnaires were in...

Control and treatment of these infections is difficult: no vaccines are available, vector control programs have ceased or are threatened by insecticide resistance, and the repertoire of effective drugs is very limited. Onchocerciasis is currently treated with ivermectin; the drugs used for lymphatic filariasis are albendazole, diethylcarbamazine (DEC) and ivermectin. None of these is effective ...

Ivermectin is widely prescribed as a potential treatment for coronavirus disease 2019, despite uncertainty about its clinical benefit. To determine whether ivermectin an efficacious mild 2019 the objective of study. A total 476 adult patients with symptoms 7 d or fewer in Jinan, China, were enrolled and followed up. Patients randomly selected to receive ivermectin, 300 μg/ kg body weight per da...

gamma-aminobutyric acid (gaba) is an important inhibitory transmitter in central nervous system and is involved in pathophysiology of epilepsy. pentylenete-trazole (ptz), a convulsant agent, partly acts via anion channel of gabaa receptor. ivermectin, an antiparasitic agent and a gabaa agonist, has anticonvulsant effect in animal seizure models. cholestasis increases the threshold of ptz-induce...