Induction therapy a. Combination treatment with cyclophosphamide plus prednisolone should be used for induction of disease remission when organ function is threatened. Both intravenous (IV) and oral cyclophosphamide show equal clinical efficacy and toxicity. (Level II evidence) b. Methotrexate is an alternative to cyclophosphamide-based induction therapy in patients with milder, early disease (...

Ibrahim M, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-221399 Description A 67-year-old man with history of tobacco smoking presents to the emergency department with sudden onset, retrosternal chest pain radiating to the neck and associated with diaphoresis and nausea. On examination, his blood pressure was 106/42 mm Hg, pulse of 73 beat/min. He was pale, diaphoretic with IV/VI diastolic blo...

An interim disease evaluation was suggestive for a complete clinical, metabolic and radiologic response. Three weeks after the completion of the 4th cycle of chemotherapy, he presented a rapid progression of dyspnea and severe hypoxemia with dry cough. The CT scan showed diffuse interstitial and alveolar in iltrates associated with a pneumomediastinum. Because of acute respiratory failure, he r...

In slices of visual cortex, long-term potentiation (LTP) of synaptic responses in layer III can be evoked by high-frequency stimulation of a site in the middle of the cortical thickness, corresponding mainly to layer IV. In contrast, stimulation of the white matter-layer VI border typically fails to evoke LTP in adult visual cortex unless GABAA receptors are partially blocked. We performed curr...

One of the main controlling parameters in diesel engine combustion is the fuel – air mixing process that has direct effects on engine performance and pollutant emissions, reviewing over previous literature showed that split injection strategies could satisfy this purpose very well. For the first time and in this paper, pilot and double injection strategies were combined and formed new triple in...

BACKGROUND Ambulatory oxygen is an important component of long-term oxygen therapy. Pulse-dose technology conserves oxygen and thus increases the operation time of a portable oxygen system. METHODS We tested 4 ambulatory oxygen systems (Helios, HomeFill, FreeStyle, and the compressed-oxygen cylinder system we regularly provide for long-term oxygen therapy at our Veterans Affairs hospital) wit...

In normal men, the majority of GH secretion occurs in a single large postsleep onset pulse that is suppressed during total sleep deprivation. We examined the impact of semichronic partial sleep loss, a highly prevalent condition, on the 24-h growth hormone profile. Eleven young men were studied after six nights of restricted bedtimes (0100-0500) and after 7 nights of extended bedtimes (2100-090...

Extensive rainfall disaggregation approaches have been developed and applied in climate change impact studies such as flood risk assessment and urban storm water management.In this study, five rainfall models that were capable ofdisaggregating daily rainfall data into hourly one were investigated for the rainfall record in theChangi Airport, Singapore. The objectives of this study were (i) to s...

STUDY OBJECTIVES To assess the effectiveness of pulse oximetry and radioisotope measurement of right-to-left (R-L) shunt for the early detection of pulmonary arteriovenous malformations (PAVMs) in patients with hereditary hemorrhagic telangiectasia (HHT). DESIGN Patients with HHT had serial measurements of the following: (1) arterial oxygen saturation (SaO2) by pulse oximetry in erect and sup...