نتایج جستجو برای: iv fentanyl
تعداد نتایج: 185286 فیلتر نتایج به سال:
15 Background: Ritonavir inhibition of cytochrome p450 3A4 decreases the elimination 16 clearance of fentanyl by 67%. We used a pharmacokinetic model developed from published 17 data to simulate the effect of sample patient-controlled epidural labor analgesic regimens on 18 plasma fentanyl concentrations in the absence and presence of ritonavir-induced cytochrome 19 p450 3A4 inhibition. 20 Meth...
Abstract Background: The aim of this study was comparison of sedation and analgesia between two drug combinations i.e. propofol+ fentanyl and ketamine+fentanyl, in patients with End stage renal disease, (ESRD) who were candidates for insertion of ‘Perm Cath’ catheter for the purpose of hemodialysis. Methods: Fifty one candidates for ‘perm cath’ catheter insertion were enrolled in this st...
Recently, decreased activity levels have been observed in pigs treated postoperatively with transdermal delivery of fentanyl (TD-fentanyl) after isoflurane anaesthesia. Whether the change in behaviour is related to opioid-induced sedation or to insufficient pain relief remains to be investigated. This study was therefore undertaken to evaluate the effect of TD-fentanyl 50 microg h(-1) on the ac...
Fentanyl is used for pain treatment during pregnancy in human beings and animals. However, fentanyl pharmacokinetics during pregnancy has not been fully established. The aim of this study was to characterize fentanyl pharmacokinetics in pregnant sheep after intravenous and transdermal dosing during surgical procedure performed to ewe and foetus. Pharmacokinetic parameters reported for non-pregn...
BackgroundRecent studies suggest that volatile anaesthetics are safe, efficient, and reliable alternatives to the use of intravenous for out-of-hospital cardiac arrest (OHCA) patients admitted intensive care unit (ICU). We hypothesised may reduce incidence delirium rather than sedatives. This retrospective study aimed investigate whether sevoflurane combined with higher targeted temperature man...
The synthetic opioid fentanyl undergoes extensive metabolism in humans. Systemic elimination occurs primarily by hepatic metabolism. When administered as a lozenge for oral transmucosal absorption, swallowed fentanyl is subject to first pass metabolism in the liver and possibly small intestine. Little is known, however, about the identity and formation of human fentanyl metabolites. This invest...
Background: Cataract is one of the most common eye diseases especially in children and adolescents in two age ranges, and many of these patients need to surgery throughout life. The purpose of this study was to compare the efficacy and side effects of midazolam-ketamine and midazolam-fentanyl for sedation in adult cataract surgery. Methods: In this study, which was a case-control study, 80 pat...
OBJECTIVE The objectives of the study were to determine the absolute bioavailability of fentanyl from fentanyl buccal soluble film, estimate the percentage of a fentanyl dose absorbed through the buccal mucosa, and compare the bioavailability of equivalent doses administered either as single or multiple dose units. DESIGN Open-label, randomized, four-period, Latin-square crossover pharmacokin...
While opioid abuse is an established medical and public health issue, the increased availability of highly potent synthetic opioids, such as fentanyl, has given rise to acute health complications, including a comatose state and death during drug overdose. Since respiratory depression that leads to acute hypoxia is the most dangerous complication of opioid drug use, we examined the effects of in...
conclusions the combination of intravenous paracetamol 1 gr and ketamine 0.5 mg/kg resulted in an overall reduction in pain scores, decreased postoperative analgesic requirements, and lower agitation score compared with intravenous paracetamol 1 gr and tramadol 0.7 mg/kg for patients undergoing renal surgery. results postoperative pain scores were significantly lower in the pk group than in the...
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