Of 34 tyrosine residues in insulin receptor substrate 1 (IRS-1), 14 are adjacent to acidic residues, suggesting that they might be phosphorylation sites. Synthetic peptides corresponding to sequences surrounding these tyrosines were used as substrates of the insulin receptor kinase. Surprisingly six of these, each within YMXM motifs, were phosphorylated with greatest efficiency (Km, 24-92 micro...

Neurolinguistics studies the relation of language processes to the brain. It is well established that the critical brain regions for language include the perisylvian association cortex, lateralized to the left in most right-handed individuals. It is becoming increasingly clear that other brain regions are part of one or more complex systems that support language operations. Evidence regarding t...

Texture boundary detection (or segmentation) is an important capability in human vision. Usually, texture segmentation is viewed as a 2D problem, as the definition of the problem itself assumes a 2D substrate. However, an interesting hypothesis emerges when we ask a question regarding the nature of textures: What are textures, and why did the ability to discriminate texture evolve or develop? A...

We study a simple model of a forager as a walk that modifies a relaxing substrate. Within it simplicity, this provides an insight on a number of relevant and non-intuitive facts. Even without memory of the good places to feed and no explicit cost of moving, we observe the emergence of a finite home range. We characterize the walks and the use of resources in several statistical ways, involving ...

Conventional approaches to understanding consciousness are generally concerned with the contribution of specific brain areas or groups of neurons. By contrast, it is considered here what kinds of neural processes can account for key properties of conscious experience. Applying measures of neural integration and complexity, together with an analysis of extensive neurological data, leads to a tes...

This paper presents a system for modeling lichens and simulating their propagation and growth in a virtual scene. Lichens colonize almost every substrate in nature and play an important role in the visual appearance of a natural object. The propagation of lichens over the substrate is performed by an Open Diffusion Limited Aggregation model constrained by the characteristics of the environment....

The low coverage adsorption of alkalis on metal surfaces induces excited states localised on the adsorbate. In the case of noble metal substrates, these excited states can exhibit a very long lifetime, up to tens of fs in the Cs/Cu(111) system. We review recent experimental and theoretical investigations of alkalis adsorbed on noble metal surfaces, with emphasis on the characteristics of the al...

in cell-substratum contact sites. homologous to a v-src substrate and is located overexpressed in human carcinomas, is The product of the EMS1 gene, amplified and

Experiments of particle-laden inclined film flow [Zhou, Dupuy, Bertozzi, and Hosoi, Phys. Rev. Lett. 94 (2005)] have displayed different settling behaviors depending on the particle concentration φ and angle of inclination θ, in which particles accumulate on the substrate or near the advancing contact line, or remain mixed. Zhou et al. presented a lubrication model that captures the qualitative...