The theme of this paper is the occurrence of risks within information technology and information systems investments. A taxonomy of the published classification frameworks of IT related risk is presented and a new comprehensive classification framework for IT investments (the TOPModel) is presented within the TRIP model of the risk factors and critical factors affecting IT investments. Risk man...

Governance, Risk, and Compliance (GRC) is an emerging topic in the world of business and information technology. However to date there is a lack of research on an integrated approach to GRC has hardly been researched. In this paper we construct an integrated process model for high-level IT GRC management. First, we discuss existing process models for integrated GRC. Then we set the scope of our...

To understand really new products, consumers face the challenge of constructing new knowledge structures rather simply changing existing ones. Recent research in categorization suggests that one strategy for creating representations for these new products is to use information already contained in familiar product categories. While knowledge from multiple existing categories may be relevant, li...

We propose a network-based methodology for analyzing a firm’s enterprise architecture. Our methodology uses “Design Structure Matrices” (DSMs) to capture the coupling between components in the architecture, including both business and technology-related elements. It addresses the limitations of prior work, in that it i) is based upon the actual architecture “in-use” as opposed to planned or “id...

Intrinsic flexibility of DNA has hampered the development of efficient protein-DNA docking methods. In this study we extend HADDOCK (High Ambiguity Driven DOCKing) [C. Dominguez, R. Boelens and A. M. J. J. Bonvin (2003) J. Am. Chem. Soc. 125, 1731-1737] to explicitly deal with DNA flexibility. HADDOCK uses non-structural experimental data to drive the docking during a rigid-body energy minimiza...

4 SUMMER/FALL 1999 T’S A RACE with no starting point, no fixed course, and really no rules at all: walk, run, ride, do anything you want. Form a team, as big as you like. Build any sort of machine you wish with whatever money you can get your hands on. Just get to the finish line first. That finish line isn’t a particular place but a new understanding of a symmetry (or rather, an almost symmetr...