Studies on a number of cysteine proteinases of the papain (EC 3.4.22.2) family using pyridyland pyrimidyldisulphide reactivity probes have demonstrated that the catalytic site (Cys)-S-/(His)-Im+H ion-pair states of these enzymes are produced at low pH where the enzymes are inactive and that catalytic competence is generated by protonic dissociation across pKa 4 [ 1-41. The assignment of the pKa...

We have developed a novel μ–scale membrane deflection experiment particularly suited for the investigation of submicron thin films and MEMS materials. The experiment cons ists of loading a fixed-fixed membrane with a line load that is applied to the middle of the span with a nanoindenter column. A Mirau microscope-interferometer is positioned below the membrane to observe its response to loadin...

The electroma.gnetic, noncontact transducer (EMAT) is particularly well suited to ultrasonic inspec~ tion problems where it is difficult or impossible to couple the sound into the object being tested ~ through a liquid or grease layer. For inspecting buried natural gas pipelines, the inspection process must be carried out by a self contained instrument package blown through the pipe by the gas ...

Jacques Mehler Laboratoirc de Science Cognitiv e et Psycho linguistique . CN RS-EHESS Paris France Generally, studies of speech recognitio n are related to theories of performance while studies of awareness are thought to bear upon language competence. In our concept ion, both area s or resea rch contribute to our unders tandlng of processing and of the represeetanons that the subjeds use when ...

I ever there were a crisis mo­ ment that crystallized the need for reforming the U.S. health care delivery system, this is it. The 2010 Affordable Care Act (ACA) promises to expand health insur­ ance coverage, a key first step toward improving health equity. But newly insured Americans will gain access to a strained, frag­ mented system that often fails to deliver effective, efficient care. Mea...

over centuries, the labour move­ ment fought to establish basic rights for workers, combatting the vested interests of avaricious capital­ ists and the cynicism of the state, which consigned to the workhouse those unable to find employment in the mines and fac­ tories. through collective action in the form of trades unions, then later through the political parties that were established in their...

Todorovic, Slobodan M. and Christopher J. Lingle. Pharmacounderstanding of the diversity within those Ca channels actilogical properties of T-type Ca current in adult rat sensory neuvated at more negative potentials remains more limited. Lowrons: effects of anticonvulsant and anesthetic agents. J. Neurophysvoltage-activated (LVA) Ca current, also called T-type curiol. 79: 240–252, 1998. We have...

Editor’s note: NEHA strives to provide up-to-date and relevant information on environmental health and to build part­ nerships in the profession. In pursuit of these goals, we feature a column from the Environmental Health Services Branch (EHSB) of the Centers for Disease Con­ trol and Prevention (CDC) in every issue of the Journal. In this column, EHSB and guest authors from across CDC will hi...

et al., 1982; Webster et al., 1986). Nitrogen balance research in agricultural production systems continues Fertilizer N recovery in crop production systems seldom exceeds to focus on NO3–N leaching (Jokela and Randall, 1989; 50%. Two long-term winter wheat (Triticum aestivum L.) experiments were selected for use of 15N to evaluate fertilizer recovery in Olson and Swallow, 1984). However, littl...

rejected? Why don’t all females make anti-sperm antibodies S (equivalent to glycodelin A but in seminal plasma) Clark when inseminated with spermatozoa? These fundamental quesprovides evidence that both forms of glycodelin contain tions, which present difficult intellectual and experimental immunosuppressive moieties that are mimicked by pathogenic challenges to the scientist, are yet to be res...