Solid facial oedema is a rarely described skin condition, which occurs as a complication of acne vulgaris. Its aetiopathogenesis has not yet been definitively clarified. However, it seems that the key role is played by chronic inflammation that can cause obstruction of lymphatic vessels, cellulitis, fibrosis and oedema. Inherited factors should also be kept in mind. In the course of the illness...

BACKGROUND Oral Isotretinoin is the most effective choice in the treatment of severe acne, It is the most widely prescribed teratogenic drug in the USA and Canada. Due to large number of its adverse effects and the necessity of long term use, patients have difficulties in complying with the treatment and some may refuse taking the drug. OBJECTIVES To assess knowledge, concerns and awareness o...

Folliculitis decalvans of the scalp is a recurrent, purulent follicular inflammation leading to scarring alopecia. We report on a 27-year-old man with folliculitis decalvans successfully treated with a combination of isotretinoin, corticosteroids, and clindamycin.

many properties of chemicals depend on their stereochemistry. among these, the effects of stereoisomerism on percutaneous absorption of drugs are not well studied. we have previously shown that permeation of tretinoin and isotretinoin (two geometric isomers) through hydrophilic enhancers-treated rat skin is stereoselective. as, depending on their lipophilicity, penetration enhancers can change ...

BACKGROUND The off-label use of oral isotretinoin in photoaging is a therapeutic tool that has been used by dermatologists. There are few studies to corroborate its effectiveness and durability. OBJECTIVES To assess, both clinically and histologically, the changes caused by the use of oral isotretinoin in skin photoaging as well as the duration of the effects. METHODS 20 female patients, ag...

BACKGROUND The efficacy of isotretinoin at 0.5 to 1.0 mg/kg per day in the treatment of acne is well established and considered safe, although it is sometimes not easily tolerated because of its cutaneous side effects. OBJECTIVE The purpose of this study was to determine the efficacy of low-dose isotretinoin in the treatment of acne. METHODS In this prospective, non comparative, open-label ...