نتایج جستجو برای: isotope effect

تعداد نتایج: 1670266  

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2014
Rowan A Stringer Gareth Williams Franck Picard Bindi Sohal Olivier Kretz Jeff McKenna Joel A Krauser

Deuterium isotope effects were evaluated as a strategy to optimize the pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole (NVS-CRF38), a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist. In an attempt to suppress O-demethylation of NVS-CRF38 without losing activity against the CRF1 receptor, the protons at ...

جاوید دبیری, , جواد رحیقی, , حسین قدس, , مهرداد عزیزی شمامی, ,

  Interaction of fast neutrons with oxygen atoms of cooling water in reactor core leads to the production of 16N isotope which emits 6.13 MeV gamma ray. A system is developed to measure the 16N gamma ray activity using a5.08cm ×5.08cm NaI(Tl) detector. A suitable electronic system is used to count 16N gamma rays in different reactor powers in order to calibrate the 16N system in terms of reacto...

Journal: :ChemEngineering 2021

Pd–Ag alloys are largely used as hydrogen separation membranes and, a consequence, the Pd–Ag–H system has been intensively studied. On contrary, fewer information is available for Pd–Ag–D system; thus, aim of this work to improve knowledge isotope effect on commercial Pd77Ag23 alloy, especially temperature above 200 °C. In particular, deuterium absorption measurements carried out in alloy range...

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