In acidic media, Fe(Ш) could be reduced to Fe(Ⅱ) by isoniazid, reacts with 2,2'-bipyridine form an orange complex a maximum absorption wavelength of 522 nm. According this principle, the content isoniazid can measured indirectly measuring amount Fe(Ⅱ). A new method for determination Fe(Ⅱ)-2,2'-bipyridine spectrophotometry has been established. At optimum conditions, linear relationship is good ...

The major clinical issue with TB therapy is the poor oral bioavailability of rifampicin in the presence of isoniazid in acidic medium. The present work was undertaken to develop a novel solid dosage form (tablet and capsule in capsule) comprising a immediate release rifampicin tablet, effervescent gastro retentive rifampicin tablet and an enteric coated isoniazid capsule that can differentiatel...

Latent tuberculosis infection (LTBI) and human immunodeficiency virus (HIV)-coinfection are challenges in the control of tuberculosis transmission. We aimed to assess and summarize evidence available in the literature regarding the treatment of LTBI in both the general and HIV-positive population, in order to support decision making by the Brazilian Tuberculosis Control Program for LTBI chemopr...

The present study was made to investigate the protective effect of methanolic extract of Ficus benghalensis L., Moraceae, on isoniazid-rifampicininduced hepatotoxicity in rats. Rats were divided into six different groups; group 1 served as a control, group 2 received isoniazid and rifampicin (100 mg/ kg, i.p.), in sterile water, groups 3, 4 and 5 received 100, 200 & 300 mg/kg bw, p.o. methanoli...

INTRODUCTION In Kenya, which ranks thirteenth of 27 high tuberculosis burden countries, diagnosis is based on Ziehl-Neelsen staining alone and patients are treated without information on sensitivity patterns. This study aimed to determine resistance patterns of Mycobacterium tuberculosis isolated from pulmonary samples. METHODOLOGY Pulmonary tuberculosis patients in Nairobi were randomly samp...

Isonicotinic acid hydrazide (isoniazid) causes a large increase in the salt-solubility of collagen when injected into chick embryos; this change is accompanied by the inactivation of lysyl oxidase (EC 1.4.3.13), the enzyme responsible for initiating cross-link formation in collagen and elastin. In addition, isoniazid markedly decreases the liver content of pyridoxal phosphate. The depletion of ...