No selective inhibitor for the B type of monoamine oxidase (MAO) was known until we demonstrated that C-) Deprenil, developed by us in 1964, is a preferential inhibitor of the metabolism of benzylamine and metaiodobenzylamine. Thus it was this paper which introduced C-) Deprenil, the first highly selective inhibitor of MAO-B. [The SCI® indicates that this paper has been cited in over 215 publiC...

The well-studied interaction between the MS2 coat protein and its cognate hairpin was used to test the utility of the methylphosphonate linkage as a phosphate analog. A nitrocellulose filter binding assay was used to measure the change in binding affinity upon introduction of a single methylphosphonate stereoisomer at 13 different positions in the RNA hairpin. Comparing these data to the availa...

Luciferin molecules are common luminophores found throughout the biological kingdoms. Here, electrospray ionization and tandem ion mobility spectrometry coupled with laser spectroscopy used to demonstrate that D-luciferin oxyluciferin deprotonated anions can be produced in two isomeric forms, which separated by virtue of their different collision cross sections a buffer gas. The isomers possess...

The influence of structured solids (amorphous, lamellar and 3D crystalline) on the regioselectivity dibromination naphthalene using bromine at room temperature has been investigated. more acidic amorphous catalysts an clay give rapid reactions lead to a large preponderance 1,4-dibromonaphthalene over 1,5-dibromo compound, while calcined KSF clay, bentonite material, after short reaction time gi...