Stroke is the leading cause of mortality and morbidity world wide, particularly in the elderly. Oxidative stress is an independent risk factor by inducing production of oxygen free radicals in ischemic stroke. Because a relationship may be hypothesized between paraoxanase (PON) and malondialdehyde(MDA),the aim of this study was to investigate the relationship between PON and oxidative stress wi...

The tissue content of energy-rich phosphates and glycolytic metabolites and the activity of myocardial enzymes were examined in the dog after producing myocardial infarction by ligating branches of the anterior descending and circumflex coronary arteries. The pattern of systolic fiber movement shown by a strain-gauge assembly differentiated ischemic from nonischemic portions of myocardium. In i...

Antithrombotic therapy has become an important goal for the treatment of ischemic disorders such as cerebral ischemia. Our recent studies found that Z-ligustilide (LIG), a characterized 3-n-alkylphthalide constituent of Radix Angelica sinensis essential oil, exerted significant neuroprotection against cerebral ischemic damage in several animal models. The present study evaluated the antithrombo...

INTRODUCTION The pathogenesis of perinatal hypoxic-ischemic brain damage is highly complex. OBJECTIVE The aim of this study was to assess the role of oxidative stress in hypoxic-ischemic brain injury and subsequent abnormal neurological outcome in infants with perinatal hypoxic-ischemic encephalopathy (HIE). We estimated perinatal oxidative brain damage measuring activity of glutathione perox...

The only approved pharmacological treatment for ischemic stroke is intravenous administration of plasminogen activator (tPA) to re-canalize the occluded cerebral vessel. Not only reperfusion but also tPA itself can induce an inflammatory response. Microglia are the innate immune cells of the central nervous system and the first immune cells to become activated in stroke. Neuroserpin, an endogen...

Accelerated phospholipid catabolism occurs early after the onset of myocardial ischemia and is likely to be mediated by the activation of one or more phospholipases in ischemic tissue. We hypothesized that hypoxia increases phospholipase A2(PLA2) activity in isolated ventricular myocytes, resulting in increased lysophospholipid and arachidonic acid production, contributing to arrhythmogenesis i...

Despite immunophilins being abundant in the brain,their functional role there remains unclear. Using rat models of transient focal cerebral ischemia,I investigated the effect of ischemic stress on the rotamase activity of immunophilins in the brain and examined the possible role of immunophilins in postischemic neuroprotection. I found that the rotamase activity of the FK506 binding protein cla...

Cyclin-dependent kinase 5 (CDK5) is a multifaceted protein shown to play important roles in the central nervous system. Abundant evidence indicates that CDK5 hyperactivities associated with neuronal apoptosis and death following ischemic stroke. CDK5 activity increases when its cofactor p35 cleaves into p25 during ischemia. Theoretically, inhibition of CDK5/p25 activity or reduction of p25 woul...

We ligated the left anterior descending coronary artery for 1 or 2 h in 31 purebred beagles. We did not detect any changes in beta-adrenergic receptor density or affinity when normal and ischemic zones were compared, either in the subendocardium or in the subepicardium. In the ischemic zones, there was a significant decline in all measures of adenylate cyclase activity, including activity media...

background:  gender  difference  has  been   reported  in stroke  risk factors  and  disease  history. the aim  of this study  was  to  compare  risk factors  and  the  severity  of ischemic stroke based  upon  modified rankin scale (mrs) and hospital mortality between two genders. methods: in a  cross-sectional  study, 341  patients  (44% males and 56% females with a mean age of 68.94 ± 12.74 ...