A i in 2 sample taken from a general practice of 2,800 was studied to ascertain the prevalence of hyperlipidaemia, hypertension, and smoking, all shown by prospective studies to be risk factors in coronary disease. A lipoprotein analysis by membrane filtration and nephelometry was performed on all subjects. The male subjects of this samplefrom the age group 30 to 69 years have been compared wit...

In 1954 Gertler and White found a significant deficit of group 0 patients in a series of 81 young male survivors of myocardial infarction. Between 1961 and 1966, a further 9 series of survivors ofmyocardial infarction were reported, and in 7 of these there was again a deficit of O's, the deficit being slight in 3 of the series but significant in 4 (Table I). Furthermore, Jaegermann (1962) found...

Ischaemic heart disease remains, and is likely to continue to be, the leading life threatening disease around the world. Signaling pathways have become more interesting as novel therapeutic targets in ischaemic heart disease. However, one needs to be very careful in picking the therapeutic target as one signaling molecule can activate and also cross-talk with other kinases. The activation of th...