BACKGROUND AND AIMS Infliximab (IFX) and iron sucrose (FeS) are of high value in inflammatory bowel disease (IBD). We aimed to assess the relative role of both therapies in IBD related anaemia and their safety when used in combination. METHODS IBD patients with anaemia receiving a first series of FeS infusions in addition to IFX were prospectively followed. We investigated serum kinetics of e...

Objective. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. Methods. We first individually analyzed 5 clinical studies, averaging the total iron deficit across all patients utilizing a modif...

BACKGROUND: Anemia cases in pregnant women Indonesia are still high because do not routinely take iron supplements or often referred as Tablet Tambah Darah of the side effects it causes. An alternative to this problem is intravenous administration sucrose. AIM: The purpose study was determine differences ferritin and hemoglobin (Hb) levels before after sucrose injection second third trimester a...

Anemia is a frequent complication in the maintenance hemodialysis (MHD) patients. However, data on serum hepcidin level as a guide in MHD patients are limited. We aimed to investigate the clinical significance of serum hepcidin level on erythropoiesis-stimulating agents (ESAs) and/or intravenous iron therapy among MHD patients. A total of 32 MHD patients receiving ESAs and iron therapy were enr...

patients. Methods: A cross-sectional study with a questionnaire for adverse drug reactions based on European Network for Drug Allergy (ENDA) was performed. Hospitalized patients older than 12 years of age were included. Results: A total of 150 patients were studied, 84 being female. Their ages ranged from 14 to 94 years, with an average of 55 years. The average number of medications per patient...

BACKGROUND AND AIMS Secondary thrombocytosis is a clinical feature of unknown significance. In inflammatory bowel disease (IBD), thrombocytosis is considered a marker of active disease; however, iron deficiency itself may trigger platelet generation. In this study we tested the effect of iron therapy on platelet counts in patients with IBD-associated anemia. METHODS Platelet counts were analy...

BACKGROUND The study of NAFLD in humans has several limitations. Using murine models helps to understand disease pathogenesis. AIM Evaluate the impact of 4 different diets in the production of NAFLD with emphasis on a combined high-fat plus sustained high sucrose consumption. MATERIAL AND METHODS Eight week-old male Wistar rats were divided in four groups and fed for 90 days with the follow...

Introduction Intravenous iron administration in patients treated by haemodialysis for end stage renal disease can exacerbate oxidative stress by increasing the level of free redox active iron. A way to reduce the impact of iron on oxidative stress in haemodialysis patients may be the administration of iron through arterial extracorporeal circuit. Objective The aim of our study was to compare th...

Objective: To compare the efficacy and safety of intravenous iron with blood transfusion in post partum women with symptomatic iron deficiency anaemia. Methods: Ninety women were included in the study. The inclusion criteria were: hemoglobin <9g/dl and/or haematocrit <28%, mean corpuscular volume <80fl, ferritin level <15ng/ml, and symptoms of anaemia within 48 hours of delivery. Women with pos...

OBJECTIVE To examine the effects of iron deficiency anemia on cognitive function and intelligence in children. METHODS Matched case-control study was carried out with 30 children (aged 6-12 years) with iron deficiency anemia (IDA) but without any chronic disease and with normal neuromotor development. The WISC-R intelligence test was performed before and after 4-6 months of iron/vitamin treat...